Nebbioso Marcella, Livani Maria Luisa, Santamaria Valentina, Librando Aloisa, Sepe Massimiliano
Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, Rome 00185, Italy.
S. Maria Goretti Hospital, via Guido Reni 1, Latina 04100, Italy.
Int J Ophthalmol. 2018 Dec 18;11(12):1932-1935. doi: 10.18240/ijo.2018.12.09. eCollection 2018.
To evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery.
A prospective and controlled trial including a large cohort of 1650 individuals suffering with bilateral cataract not complicated, in program by phacoemulsification surgery, were randomly assigned to 2 different groups for the type of anesthesia received, 0.4% oxybuprocaine hydrochloride (INN) drops, and INN drops associated to intracameral 1% lidocaine hydrochloride monohydrate. At the end of surgery, tables were assigned to each patient indicating the degree of pain (0-3) felt during the operation.
Thirty-two percent of patients in group 1 declared to have not felt any pain against the 77% of patients in group 2. Fifty-nine percent of patients in group 1 complained about only a slight discomfort against 20% of group 2 patients. Only a small percentage of patients in group 1 (5%) admitted severe pain, while no patient in group 2 admitted severe pain. Four patients of group 2 reported an episode of transient amaurosis, lasting several hours after surgery.
Intracameral administration of lidocaine is a simple and secure method able to increase the analgesia during the cataract surgery, eliminating the discomfort and increasing also the cooperation of the patients during the steps of manipulation.
评估前房内注射利多卡因作为经典表面麻醉滴眼液补充剂在白内障手术中的安全性、有效性和患者依从性。
一项前瞻性对照试验,纳入了1650例患有双侧未合并并发症白内障的患者队列,这些患者计划接受超声乳化手术,根据所接受的麻醉类型随机分为2组,分别使用0.4%盐酸奥布卡因(国际非专利药品名称)滴眼液,以及与前房内注射1%一水合盐酸利多卡因联合使用的盐酸奥布卡因滴眼液。手术结束时,为每位患者填写表格,表明其在手术过程中感受到的疼痛程度(0 - 3级)。
第1组32%的患者表示未感觉到任何疼痛,而第2组这一比例为77%。第1组59%的患者仅抱怨有轻微不适,而第2组这一比例为20%。第1组只有一小部分患者(5%)承认有剧痛,而第2组没有患者承认有剧痛。第2组有4名患者报告出现一过性黑矇,术后持续数小时。
前房内注射利多卡因是一种简单且安全的方法,能够增强白内障手术期间的镇痛效果,消除不适,并在操作步骤中提高患者的配合度。