视网膜母细胞瘤病理学进展
Update on pathology of retinoblastoma.
作者信息
Singh Lata, Kashyap Seema
机构信息
Department of Ocular Pathology, Dr. R.P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
出版信息
Int J Ophthalmol. 2018 Dec 18;11(12):2011-2016. doi: 10.18240/ijo.2018.12.22. eCollection 2018.
Abstract
Retinoblastoma is caused by mutational inactivation of both alleles of the gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor. Histopathological high-risk features of retinoblastoma are predictive of metastasis or local recurrence. The focus of this update is to emphasize the recent advances in pathology, various molecular key pathways and genome wide approaches for newer potential therapeutic future targets associated with retinoblastoma tumor biology. This review article highlights the new biomarkers expressed by the retinoblastoma tumor for the better survival of patients.
摘要
视网膜母细胞瘤是由该基因的两个等位基因发生突变失活引起的，该基因定位于13号染色体长臂14区，编码作为肿瘤抑制因子的视网膜母细胞瘤蛋白。视网膜母细胞瘤的组织病理学高危特征可预测转移或局部复发。本次更新的重点是强调病理学、各种分子关键途径以及全基因组方法方面的最新进展，这些进展与视网膜母细胞瘤肿瘤生物学相关，有望成为新的潜在治疗靶点。这篇综述文章强调了视网膜母细胞瘤肿瘤表达的新生物标志物，以提高患者的生存率。
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