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大体积供肝全肝移植术后肝静脉流出道梗阻:术中的综合处理

Hepatic venous outflow obstruction after whole liver transplantation of large-for-size graft: versatile intra-operative management.

作者信息

Lim Chetana, Osseis Michael, Tudisco Antonella, Lahat Eylon, Sotirov Dobromir, Salloum Chady, Azoulay Daniel

机构信息

Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Henri Mondor Hospital, Créteil, France.

Université Paris-Est UPEC, Créteil, France.

出版信息

Ann Hepatobiliary Pancreat Surg. 2018 Nov;22(4):321-325. doi: 10.14701/ahbps.2018.22.4.321. Epub 2018 Nov 27.

DOI:10.14701/ahbps.2018.22.4.321
PMID:30588522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6295374/
Abstract

BACKGROUNDS/AIMS: Preservation of the native inferior vena cava using a large graft during adult whole liver transplantation is associated with a potential risk of hepatic venous outflow compression/obstruction, which may adversely affect both graft and short-term patient outcomes. Intraoperative placement of materials to restore adequate hepatic venous outflow can overcome this complication.

METHODS

Data of patients who underwent liver transplantation between 2011 and 2016 were retrospectively reviewed. All cases of hepatic venous outflow obstruction due to large graft size managed via intraoperative intervention were analyzed. The literature was searched for studies reporting adult cases of hepatic venous outflow obstruction following whole liver transplantation managed extrahepatically.

RESULTS

Three patients diagnosed with intraoperative hepatic venous outflow obstruction due to large graft size were managed via retro-hepatic placement of breast implants (2 cases) or abdominal pads (1 case). It was successfully carried out in all cases. Four studies including 15 patients were identified in the literature search. Different types of materials such as inflatable materials (Foley catheter, Blakemore balloon), surgical gloves or breast implants, were used.

CONCLUSIONS

Placement of inflatable materials leads to gradual deflation in the postoperative period, which might obviate the need for reoperation. Breast implants could be left in place indefinitely due to their bio-inert nature.

摘要

背景/目的:在成人全肝移植期间使用大口径移植物保留原生下腔静脉与肝静脉流出道受压/梗阻的潜在风险相关,这可能对移植物和患者短期预后产生不利影响。术中放置材料以恢复足够的肝静脉流出道可克服这一并发症。

方法

回顾性分析2011年至2016年间接受肝移植患者的数据。分析所有因移植物尺寸大导致肝静脉流出道梗阻并通过术中干预处理的病例。检索文献,查找报告肝外处理成人全肝移植后肝静脉流出道梗阻病例的研究。

结果

3例因移植物尺寸大被诊断为术中肝静脉流出道梗阻的患者通过在肝后放置乳房植入物(2例)或腹部垫(1例)进行处理。所有病例均成功实施。在文献检索中确定了4项研究,共15例患者。使用了不同类型的材料,如可充气材料(福勒导尿管、布莱克莫尔球囊)、手术手套或乳房植入物。

结论

放置可充气材料会在术后逐渐放气,这可能无需再次手术。乳房植入物因其生物惰性可无限期留置。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8311/6295374/9b99d8370841/ahbps-22-321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8311/6295374/decdad91c6cd/ahbps-22-321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8311/6295374/9b99d8370841/ahbps-22-321-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8311/6295374/decdad91c6cd/ahbps-22-321-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8311/6295374/9b99d8370841/ahbps-22-321-g002.jpg

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本文引用的文献

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Extreme large-for-size syndrome after adult liver transplantation: A model for predicting a potentially lethal complication.成人肝移植术后巨大肝体积综合征:预测潜在致命并发症的模型。
Liver Transpl. 2017 Oct;23(10):1294-1304. doi: 10.1002/lt.24835.
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Venous outflow obstruction after orthotopic liver transplantation: use of a breast implant to maintain graft position.原位肝移植术后静脉流出道阻塞:使用乳房植入物维持移植物位置。
Clin Transplant. 2011 May-Jun;25(3):E320-6. doi: 10.1111/j.1399-0012.2011.01423.x. Epub 2011 Mar 9.
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Ectopic placement of Sengstaken-Blakemore device to correct outflow obstruction in liver transplantation: case reports.
基于术前三维规划在肝脏获取过程中进行右后段切除术以预防成人对成人肝移植中的极大型供肝综合征:一例报告
Quant Imaging Med Surg. 2024 Dec 5;14(12):9552-9562. doi: 10.21037/qims-24-507. Epub 2024 Nov 29.
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Outflow obstruction after living donor liver transplantation managed with a temporary vena cava filter: A case report.活体供肝移植术后流出道梗阻采用临时腔静脉滤器治疗:一例报告。
Int J Surg Case Rep. 2023 Nov;112:108981. doi: 10.1016/j.ijscr.2023.108981. Epub 2023 Oct 24.
使用Sengstaken-Blakemore装置异位放置以纠正肝移植中的流出道梗阻:病例报告
Transplant Proc. 2010 Mar;42(2):597-8. doi: 10.1016/j.transproceed.2010.01.048.
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Early venous outflow obstruction after liver transplantation and treatment with cavo-cavostomy.肝移植术后早期静脉流出道梗阻及腔静脉吻合术治疗
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