无序Z型螺旋的晶体结构

Crystal structures of disordered Z-type helices.

作者信息

Karthik S, Mandal P K, Thirugnanasambandam A, Gautham N

机构信息

a Centre of Advanced Study in Crystallography and Biophysics , University of Madras, Guindy Campus , Chennai , Tamil Nadu , India.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2019;38(4):279-293. doi: 10.1080/15257770.2018.1517883. Epub 2018 Dec 27.

DOI:10.1080/15257770.2018.1517883

PMID:30588873

Abstract

The X-ray crystal structures of a decamer sequence d(CGCGTACGCG) and a tetradecamer sequence d(CGCGCGTACGCGCG) are presented here. Both sequences are alternating pyrimidine-purine repeat sequences and they form disordered, pseudo-continuous left handed Z-type helices. They demonstrate interesting variants of the 'bundles of columns of helices' mode of packing.

摘要

本文展示了十聚体序列d(CGCGTACGCG)和十四聚体序列d(CGCGCGTACGCGCG)的X射线晶体结构。这两个序列均为嘧啶-嘌呤交替重复序列，它们形成无序的、伪连续的左手Z型螺旋。它们展示了“螺旋柱束”堆积模式的有趣变体。