细胞膜模拟共聚体包覆聚多巴胺纳米粒子用于联合 pH 敏感药物释放和近红外光热治疗。
Cell membrane mimetic copolymer coated polydopamine nanoparticles for combined pH-sensitive drug release and near-infrared photothermal therapeutic.
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710127, China.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710127, China.
出版信息
Colloids Surf B Biointerfaces. 2019 Apr 1;176:1-8. doi: 10.1016/j.colsurfb.2018.12.057. Epub 2018 Dec 21.
In this study, we modified the well-known photothermal polydopamine nanoparticles with the poly[(2-methacryloyloxy)ethyl phosphorylcholine-b-(2-dimethylamino)ethyl methacrylate] (PMPC-b-PDMAEMA) diblock copolymers, containing both biocompatible cell membrane phosphorylcholine zwitterions segments and pH-responsive dimethylaminoethyl units on the polymer chains, to achieve both the photothermal property and pH-responsive release behavior. The results showed that the obtained nanoparticles had a narrow size distribution with the diameter about 220 nm. Besides, the modified polydopamine nanoparticles showed enhanced colloidal stability, pH-sensitive drug release behavior, excellent biocompatibility and remarkable near-infrared photothermal property. Thus, it is highly anticipated that PMPC-b-PDMAEMA modified polydopamine nanoparticles can serve as a powerful drug delivery system for combined pH-sensitive drug release and near-infrared photothermal therapeutic.
在这项研究中，我们用聚[（2-甲基丙烯酰氧基）乙基磷酸胆碱-b-（2-二甲氨基）乙基甲基丙烯酸酯]（PMPC-b-PDMAEMA）两亲性嵌段共聚物对著名的光热聚多巴胺纳米粒子进行了修饰，该共聚物含有生物相容性细胞膜磷酸胆碱两性离子段和聚合物链上的 pH 响应性二甲氨基乙基单元，以实现光热性能和 pH 响应性释放行为。结果表明，所得到的纳米粒子的直径约为 220nm，具有较窄的粒径分布。此外，修饰后的聚多巴胺纳米粒子表现出增强的胶体稳定性、pH 敏感的药物释放行为、良好的生物相容性和优异的近红外光热性能。因此，有望将 PMPC-b-PDMAEMA 修饰的聚多巴胺纳米粒子用作用于联合 pH 敏感药物释放和近红外光热治疗的有效药物传递系统。
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