NAFLD Research Center, University of California, San Diego, La Jolla.
KineMed, Inc., Emeryville.
Clin Infect Dis. 2019 Jul 18;69(3):542-545. doi: 10.1093/cid/ciy1100.
In a pilot study, heavy water labeling was used to determine hepatitis B surface antigen (HBsAg) turnover rates in chronic hepatitis B (CHB) patients. The mean (standard deviation) half-life of HBsAg in blood was 6.7 (5.5) days, which reflects recent production in the liver and supports strategies aimed at reducing HBsAg production in CHB patients.
在一项初步研究中,使用重水标记来确定慢性乙型肝炎 (CHB) 患者的乙型肝炎表面抗原 (HBsAg) 周转率。HBsAg 在血液中的平均(标准差)半衰期为 6.7(5.5)天,这反映了肝脏的近期产生,并且支持旨在降低 CHB 患者 HBsAg 产生的策略。