Center for Inflammatory Bowel Diseases, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Inflamm Bowel Dis. 2019 May 4;25(6):998-1005. doi: 10.1093/ibd/izy376.
As patients with inflammatory bowel disease (IBD) are living longer and our medical armamentarium expands, gastroenterologists are more frequently faced with treatment decisions about patients with IBD who also have a history of malignancy. This review aims to summarize the current literature on IBD, the inherent risk of developing gastrointestinal and extra-intestinal malignancies, and the risk of malignancies associated with available biologic and immunomodulatory therapies and to discuss the overall treatment strategy for a patient with a history of malignancy.
随着炎症性肠病(IBD)患者的寿命延长,以及我们的医学手段不断扩展,越来越多的胃肠病学家需要面对患有 IBD 且有恶性肿瘤病史的患者的治疗决策。本文旨在总结目前关于 IBD 的文献、发生胃肠道和肠外恶性肿瘤的固有风险,以及与现有生物制剂和免疫调节剂治疗相关的恶性肿瘤风险,并讨论有恶性肿瘤病史患者的整体治疗策略。