Cui Wan-Hua, Wang Yan-Zhi, Li Ze-Zhi, Guo Yan, Gao Mei-Ling, Cheng Yong-Xian, Feng Wei-Sheng
a School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou 450046 , China.
b Department of Respiratory Diseases and Clinical Medicine , Collaborative Innovation Center for Henan Province , Zhengzhou 450046 , China.
J Asian Nat Prod Res. 2019 Jan;21(1):1-8. doi: 10.1080/10286020.2018.1545761. Epub 2018 Dec 27.
Four new diarylheptanoids, (1S, 3R, 5R, 6R)-1, 5-epoxy-3, 6 dihydroxy-1-(4-hydroxy-3, 5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl) heptane (1), (1R, 3R, 5S)-1, 5-epoxy-3-acetoxy-1-(4, 5-dihydroxy-3-methoxyphenyl)-7-(3, 4- hydroxyphenyl) heptane (2), (3R, 5S, 6R, 7S)-3, 6-epoxy-7-hydroxyl-1-(4-hydroxyphenyl)-7-(3-methoxy-4-hydroxyphenyl) heptane (3), (E)-3-keto-1-(3-methoxy-4-hydroxyphenyl)-7-(4, 5-dihydroxy-3-methoxyphenyl)-4- heptene (4), were isolated from Rhizoma Zingiberis, and their structures were determined based on HR-ESI-MS and extensive spectroscopic techniques (UV, IR, 1D-NMR and 2D-NMR). Compounds 1-4 exhibited no cytotoxicity against HepG2 cell lines.
从干姜中分离出四种新的二芳基庚烷类化合物，即(1S, 3R, 5R, 6R)-1, 5-环氧-3, 6-二羟基-1-(4-羟基-3, 5-二甲氧基苯基)-7-(4-羟基-3-甲氧基苯基)庚烷(1)、(1R, 3R, 5S)-1, 5-环氧-3-乙酰氧基-1-(4, 5-二羟基-3-甲氧基苯基)-7-(3, 4-二羟基苯基)庚烷(2)、(3R, 5S, 6R, 7S)-3, 6-环氧-7-羟基-1-(4-羟基苯基)-7-(3-甲氧基-4-羟基苯基)庚烷(3)、(E)-3-酮-1-(3-甲氧基-4-羟基苯基)-7-(4, 5-二羟基-3-甲氧基苯基)-4-庚烯(4)，并通过高分辨电喷雾电离质谱(HR-ESI-MS)和广泛的光谱技术(紫外光谱、红外光谱、一维核磁共振和二维核磁共振)确定了它们的结构。化合物1-4对肝癌细胞系HepG2无细胞毒性。
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