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[儿童颅内动脉瘤。一项合作研究。基于43例病例]

[Intracranial arterial aneurysm in children. A cooperative study. Apropos of 43 cases].

作者信息

Roche J L, Choux M, Czorny A, Dhellemmes P, Fast M, Frerebeau P, Lapras C, Sautreaux J L

机构信息

Hôpital Pasteur, Nice.

出版信息

Neurochirurgie. 1988;34(4):243-51.

PMID:3059206
Abstract

This joint study describes 43 cases of intracranial arterial aneurysms in children diagnosed on the basis of clinical symptoms. In the pediatric age group, this malformation is notable because of the marked sex predilection in males (70%) and an unequal topographic incidence in the circle of Willis, where carotid artery (39.3%) and anterior communicating artery lesions (30%) predominate. The most frequent clinical sign was subarachnoid hemorrhage (81%), although symptoms caused by compression revealed the abnormality in 2.3% of patients. In this series, 11% of the patients suffered a head injury at the time of the hemorrhagic accident; this finding has been reported previously in the literature. Today, treatment is always surgical, consisting in removal of the aneurysmal sac. Surgical results are encouraging; all grade lesions considered together, 63.4% of the children were cured without any sequelae, 19.5% lost one school year but were able to lead a normal life, and 4.8% remained severely handicapped; overall postoperative mortality was 12.3%. Cerebral plasticity and tolerance of spasm in children are fundamental features of this aneurysmal pathology which partially explain the favorable results obtained with surgery.

摘要

这项联合研究描述了43例根据临床症状确诊的儿童颅内动脉瘤病例。在儿童年龄组中,这种畸形很显著,因为男性有明显的性别偏好(70%),并且在Willis环中地形发生率不平等,其中颈动脉病变(39.3%)和前交通动脉病变(30%)占主导。最常见的临床体征是蛛网膜下腔出血(81%),尽管压迫引起的症状在2.3%的患者中揭示了异常。在这个系列中,11%的患者在出血事故时头部受伤;这一发现先前已在文献中报道。如今,治疗总是手术治疗,包括切除动脉瘤囊。手术结果令人鼓舞;综合考虑所有分级病变,63.4%的儿童治愈且无任何后遗症,19.5%的儿童耽误了一学年但能够过上正常生活,4.8%的儿童仍严重残疾;总体术后死亡率为12.3%。儿童的脑可塑性和对痉挛的耐受性是这种动脉瘤病理的基本特征,这部分解释了手术取得的良好结果。

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