Morey L C, Ban T A, Cassano G, Santini V, Placidi G F, Modafferi A, Postiglione A
Department of Psychology, Vanderbilt University, Nashville, Tenn.
Neuropsychobiology. 1988;19(3):135-8. doi: 10.1159/000118448.
In a multicenter clinical trial, two dosages of glycosaminoglycan polysulfate were compared in patients with primary degenerative dementia and multi-infarct dementia. Psychopathologic symptoms were assessed using the Brief Psychiatric Rating Scale (BPRS). A factor analysis of this scale revealed four factors in this population. During the clinical trial, significant improvements were noted on the primary BPRS factor (i.e. depressive withdrawal), as well as on total BPRS score. There was a tendency for greater improvement in the primary degenerative dementia group than in the multi-infarct dementia group.
在一项多中心临床试验中，对原发性退行性痴呆和多发性梗死性痴呆患者比较了两种剂量的硫酸氨基葡聚糖。使用简明精神病评定量表（BPRS）评估精神病理症状。对该量表的因素分析显示该人群中有四个因素。在临床试验期间，主要BPRS因素（即抑郁退缩）以及BPRS总分均有显著改善。原发性退行性痴呆组比多发性梗死性痴呆组有更大改善的趋势。
