Yin Chun-Ping, Li Ya-Nan, Zhao Juan, Zhang Qi, Guo Yang-Yang, Gao Fang, Wang Xiu-Li, Wang Qiu-Jun
Department of Anesthesiology, The Third Hospital of Hebei Medical University.
Department of Anesthesiology, Children's Hospital of Hebei Province, Shijiazhuang, China.
Medicine (Baltimore). 2018 Dec;97(52):e13814. doi: 10.1097/MD.0000000000013814.
Transcutaneous electrical acupoint stimulation (TEAS) is a emerging treatment which combines transcutaneous electrical nerve stimulation with traditional acupoint therapy. The present study was aimed to evaluate the effect of TEAS on the effective concentration (EC50) of remifentanil suppressing tracheal extubation response in elderly patients.Fifty-three patients undergoing spine surgery were randomly divided into 2 groups: control group (group C, n = 26) and transcutaneous electrical acupoint stimulation group (group TEAS, n = 27). The EC50 values for remifentanil TCI were determined using sequential method and probit analysis.The remifentanil EC50 of that suppressed responses to extubation during anesthetic emergence was 1.20 ng/mL in group TEAS, a value that was significantly lower than the 1.64 ng/mL needed by patients in group C.The TEAS can enhance the efficacy of remifentanil on suppressing responses to tracheal extubation in elderly patients, the EC50 of remifentanil can reduce approximately 27% compared with group C.
经皮穴位电刺激（TEAS）是一种将经皮电刺激神经与传统穴位疗法相结合的新兴治疗方法。本研究旨在评估经皮穴位电刺激对老年患者瑞芬太尼抑制气管拔管反应有效浓度（EC50）的影响。53例接受脊柱手术的患者被随机分为两组：对照组（C组，n = 26）和经皮穴位电刺激组（TEAS组，n = 27）。采用序贯法和概率分析确定瑞芬太尼靶控输注的EC50值。TEAS组在麻醉苏醒期抑制拔管反应的瑞芬太尼EC50为1.20 ng/mL，该值显著低于C组患者所需的1.64 ng/mL。经皮穴位电刺激可增强瑞芬太尼对老年患者气管拔管反应的抑制效果，与C组相比，瑞芬太尼的EC50可降低约27%。
