Hou Zhi-Tao, Han Yu-Sheng, Liu Yi-Tian, Xing Yu, Wang Meng, Chen Jing
School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2018 Nov;43(22):4506-4512. doi: 10.19540/j.cnki.cjcmm.20180724.005.
Type 2 diabetes mellitus (T2DM) is the leading threat to human health in China, and severe cognitive impairment often occurs in most T2DM patients. Although Sagacious Confucius' Pillow Elixir is a type of classical traditional Chinese medicine for cognitive impairment in clinic, the mechanism has not yet been completely defined. In this study, an experimental model of type 2 diabetes mellitus (T2DM) was established by injecting Sprague Dawley (SD) rats with streptozocin (STZ), so as to compare the learning and memory ability, hippocampal neurons pathological changes, beta amyloid protein (A beta) content, degree of Tau protein phosphorylation, blood glucose and insulin level. The results showed that the Sagacious Confucius' Pillow Elixir could improve the learning and memory ability of STZ injected rats, reduce the level of A beta content both in hippocampus and serum, effectively reduce Tau protein phosphorylation degree, and also significantly alleviate hippocampal pathological injury, blood glucose, insulin and other basic indicators. The results showed that Sagacious Confucius' Pillow Elixir can alleviate the hippocampal pathological damage caused by STZ, and is expected to provide a theoretical basis for human T2DM patients in clinical adjuvant therapy.
2型糖尿病（T2DM）是中国人类健康的主要威胁，大多数T2DM患者常出现严重的认知障碍。虽然孔圣枕中丹是临床上治疗认知障碍的一种经典中药，但作用机制尚未完全明确。本研究通过给Sprague Dawley（SD）大鼠注射链脲佐菌素（STZ）建立2型糖尿病（T2DM）实验模型，以比较其学习记忆能力、海马神经元病理变化、β淀粉样蛋白（Aβ）含量、Tau蛋白磷酸化程度、血糖和胰岛素水平。结果表明，孔圣枕中丹可提高注射STZ大鼠的学习记忆能力，降低海马和血清中Aβ含量水平，有效降低Tau蛋白磷酸化程度，还可显著减轻海马病理损伤、血糖、胰岛素等基础指标。结果表明，孔圣枕中丹可减轻STZ所致的海马病理损伤，有望为人类T2DM患者临床辅助治疗提供理论依据。
