Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
King's College London, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.
Mol Brain. 2018 Dec 28;11(1):76. doi: 10.1186/s13041-018-0419-y.
Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on 'Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)'. John had no opportunity to read the referees' comments, and as a mark of the regard in which he was held by the neuroscience community the Editors decided to publish his review as submitted. This obituary takes the form of a series of commentaries on Lisman's review. At the same time we are publishing as a separate article a longer response by Todd Sacktor and André Fenton entitled 'What does LTP tell us about the roles of CaMKII and PKMζ in memory?' which presents the case for a rival memory molecule, PKMζ.
2017 年 10 月去世前不久，约翰·利斯曼（John Lisman）向《分子大脑》（Molecular Brain）提交了一篇题为“识别记忆痕迹分子基础的标准（CaMKII、PKMζ）”的特邀评论。约翰没有机会阅读审稿人的意见，而作为他在神经科学界受到尊敬的标志，编辑们决定按原样发表他的评论。这篇讣告采用了一系列对利斯曼评论的评论。与此同时，我们还作为一篇单独的文章发表了托德·萨克托（Todd Sacktor）和安德烈·芬顿（André Fenton）的一篇更长的回应，题为“LTP 告诉我们 CaMKII 和 PKMζ 在记忆中的作用是什么？”，提出了另一种记忆分子 PKMζ 的观点。
