Majid Atif, Blackwell Miranda, Broadbent Roland S, Barker David P, Al-Sallami Hesham S, Edmonds Liza, Kerruish Nikki, Wheeler Benjamin J
Department of Women's and Children's Health, Dunedin School of Medicine.
School of Pharmacy, and.
Hosp Pediatr. 2019 Jan;9(1):55-60. doi: 10.1542/hpeds.2018-0104.
Since its initial discovery almost a century ago, vitamin K has been labeled as both lifesaving and malignancy causing. This has led to debate of not only its use in general but also regarding its appropriate dose and route. In this article, we review through a historical lens the past 90 years of newborn vitamin K from its discovery through to its modern use of preventing vitamin K deficiency bleeding (VKDB). Although researchers in surveillance studies have shown considerable reductions in VKDB following intramuscular vitamin K prophylaxis, ongoing barriers to the universal uptake of vitamin K prophylaxis remain. Reviewing the history of newborn vitamin K provides an opportunity for a greater understanding of the current barriers to uptake that we face. Although at times difficult, improving this understanding may allow us to address contentious issues related to parental and health professional beliefs and values as well as improve overall communication. The ultimate goal is to improve and maintain the uptake of vitamin K to prevent VKDB in newborns.
自近一个世纪前首次发现以来，维生素K既被视为救命良药，又被认为会引发恶性肿瘤。这不仅引发了关于其总体用途的争论，还涉及到合适剂量和给药途径的问题。在本文中，我们将透过历史的视角，回顾过去90年来新生儿维生素K从发现到现代用于预防维生素K缺乏性出血（VKDB）的历程。尽管监测研究中的研究人员表明，肌肉注射维生素K预防后VKDB有显著减少，但维生素K预防普遍应用仍存在持续障碍。回顾新生儿维生素K的历史为更好地理解我们目前面临的应用障碍提供了契机。尽管有时困难重重，但增进这种理解可能使我们能够解决与家长和医疗专业人员的信念及价值观相关的争议性问题，并改善整体沟通。最终目标是提高并维持维生素K的应用率，以预防新生儿VKDB。
