Elarabi Anam M, Mosleh Eman, Alamlih Laith I, Albakri Mutaz M, Ibrahim Wanis H
Department of Pulmonology, Hamad Medical Corporation, Doha, Qatar.
Department of Pediatrics, St. John's Hospital, Southern Illinois University School of Medicine, Springfield, IL, USA.
Am J Case Rep. 2018 Dec 29;19:1541-1545. doi: 10.12659/AJCR.911572.
BACKGROUND The clinical presentation in acromegaly is usually insidious, with headaches or visual disturbances being the most common symptoms. Previous studies have shown higher fibrinogen levels, lower protein C and S activity values, and enhanced platelet function in patients with acromegaly compared to a normal population. Nevertheless, the link between hypercoagulability and acromegaly is often overlooked and rarely reported in the literature. CASE REPORT We report a case of a young man with a massive pulmonary embolism as the initial presentation of acromegaly. Extensive workup excluded other causes of thrombophilia. Furthermore, the diagnosis of acromegaly was confirmed by the patient's clinical features as well as laboratory and radiological testing. A literature review on the link between hypercoagulability and acromegaly was performed. CONCLUSIONS This case report shed light on hypercoagulability as an under-recognized serious complication of acromegaly and paves the road for future studies on this topic.
肢端肥大症的临床表现通常较为隐匿，头痛或视觉障碍是最常见的症状。既往研究表明，与正常人群相比，肢端肥大症患者的纤维蛋白原水平较高，蛋白C和S活性值较低，血小板功能增强。然而，高凝状态与肢端肥大症之间的联系常常被忽视，且在文献中鲜有报道。病例报告：我们报告一例年轻男性，以大面积肺栓塞为肢端肥大症的首发表现。全面检查排除了其他血栓形成倾向的原因。此外，通过患者的临床特征以及实验室和影像学检查确诊为肢端肥大症。对高凝状态与肢端肥大症之间的联系进行了文献综述。结论：本病例报告揭示了高凝状态是肢端肥大症一种未被充分认识的严重并发症，并为该主题的未来研究铺平了道路。
