转移性心脏肿瘤：文献综述及对睾丸肿瘤转移至右心室的自身观察

Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart.

作者信息

Zakhartseva L M, Zakharova V P, Shatrova K M, Chitaeva G E, Vitovsky R M

机构信息

Bogomolets National Medical University, Kyiv 03115, Ukraine.

Amosov National Institute of Cardiovascular Surgery, Kyiv 02000, Ukraine.

出版信息

Exp Oncol. 2018 Dec;40(4):336-342.

PMID:30593757

Abstract

BACKGROUND

Tumors of the heart are uncommon and usually benign (in 93% cases myxomas are observed). More often secondary, metastatic tumors are detected in the heart, as a rule, at pronounced progression of the malignant neoplasm with multiple lesions of other internal organs (lung, pleura, liver, etc.). Literature review on cardiac metastases of different tumors is given.

CASE REPORT

Own observation of a young man with rare single metastasis of malignant testicular germ cell tumor with predominance of embryonic carcinoma in the right ventricle of the heart is presented; the primary tumor was detected after metastasis revealing. The diagnostic algorithm using routine histological study supplemented with immunohistochemistry, including detection of cytokeratin pan, cytokeratin 5/6, cytokeratin 7, CD30, OCT4, TTF-1, hCG, and AFP markers expression, is described.

摘要

背景

心脏肿瘤并不常见，通常为良性（93%的病例为黏液瘤）。更常见的是继发性转移性肿瘤，通常在恶性肿瘤明显进展且其他内脏器官（肺、胸膜、肝脏等）出现多处病变时在心脏中被检测到。本文对不同肿瘤的心脏转移进行了文献综述。

病例报告

介绍了对一名年轻男性的观察，该患者患有罕见的恶性睾丸生殖细胞肿瘤单发转移，以胚胎癌为主，转移至右心室；在发现转移后检测到原发性肿瘤。描述了使用常规组织学研究并辅以免疫组织化学的诊断算法，包括检测广谱细胞角蛋白、细胞角蛋白5/6、细胞角蛋白7、CD30、OCT4、甲状腺转录因子-1、人绒毛膜促性腺激素和甲胎蛋白标志物的表达。