Zakhartseva L M, Zakharova V P, Shatrova K M, Chitaeva G E, Vitovsky R M
Bogomolets National Medical University, Kyiv 03115, Ukraine.
Amosov National Institute of Cardiovascular Surgery, Kyiv 02000, Ukraine.
Exp Oncol. 2018 Dec;40(4):336-342.
Tumors of the heart are uncommon and usually benign (in 93% cases myxomas are observed). More often secondary, metastatic tumors are detected in the heart, as a rule, at pronounced progression of the malignant neoplasm with multiple lesions of other internal organs (lung, pleura, liver, etc.). Literature review on cardiac metastases of different tumors is given.
Own observation of a young man with rare single metastasis of malignant testicular germ cell tumor with predominance of embryonic carcinoma in the right ventricle of the heart is presented; the primary tumor was detected after metastasis revealing. The diagnostic algorithm using routine histological study supplemented with immunohistochemistry, including detection of cytokeratin pan, cytokeratin 5/6, cytokeratin 7, CD30, OCT4, TTF-1, hCG, and AFP markers expression, is described.
心脏肿瘤并不常见，通常为良性（93%的病例为黏液瘤）。更常见的是继发性转移性肿瘤，通常在恶性肿瘤明显进展且其他内脏器官（肺、胸膜、肝脏等）出现多处病变时在心脏中被检测到。本文对不同肿瘤的心脏转移进行了文献综述。
介绍了对一名年轻男性的观察，该患者患有罕见的恶性睾丸生殖细胞肿瘤单发转移，以胚胎癌为主，转移至右心室；在发现转移后检测到原发性肿瘤。描述了使用常规组织学研究并辅以免疫组织化学的诊断算法，包括检测广谱细胞角蛋白、细胞角蛋白5/6、细胞角蛋白7、CD30、OCT4、甲状腺转录因子-1、人绒毛膜促性腺激素和甲胎蛋白标志物的表达。
