正常和病理性衰老中的白质病变的认知影响。

Cognitive Effects of White Matter Pathology in Normal and Pathological Aging.

机构信息

Department of Psychology, Åbo Akademi University, Finland.

Turku PET-Centre, University of Turku, Finland.

出版信息

J Alzheimers Dis. 2019;67(2):489-493. doi: 10.3233/JAD-180554.

DOI:10.3233/JAD-180554

PMID:30594927

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6484248/

Abstract

We examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer's disease (total n = 149), controlling for age and education. Trend-level effects of white matter pathology on cognition were only observed in patients with Alzheimer's disease (p = 0.062, η2 = 0.052), patients with severe frontal white matter pathology performed notably worse than those with milder pathology. This indicates that frontal cerebrovascular pathology may have an additive negative effect on cognition in Alzheimer's disease.

摘要

我们研究了认知正常的老年人、轻度认知障碍患者和阿尔茨海默病患者（共 149 人）的大脑血管白质病变是否与 CERAD 神经心理学测试的复合评分所衡量的认知有关，同时控制了年龄和教育程度。白质病变对认知的趋势影响仅在阿尔茨海默病患者中观察到（p=0.062，η2=0.052），严重额叶白质病变的患者表现明显比轻度病变患者差。这表明额叶脑血管病变可能对阿尔茨海默病患者的认知有额外的负面影响。