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Clinical characteristics and treatment outcome of patients with isochromosome 17q (i17q) abnormality and myeloid neoplasms: A single center experience.

作者信息

Ganguly Siddhartha, Uvodich Mason, Dias Ajoy, McGuirk Joseph P

机构信息

Division of Hematological Malignancies and Cellular Therapeutics, University of Kansas Health System, 2330 Shawnee Mission Parkway; Suite 210, Westwood, Kansas 66207, USA.

出版信息

Leuk Res Rep. 2018 Jun 20;10:55-56. doi: 10.1016/j.lrr.2018.06.002. eCollection 2018.

DOI:10.1016/j.lrr.2018.06.002
PMID:30596010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6308020/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c7/6308020/4f64279f459d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c7/6308020/4f64279f459d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26c7/6308020/4f64279f459d/gr1.jpg

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Clinical characteristics and treatment outcome of patients with isochromosome 17q (i17q) abnormality and myeloid neoplasms: A single center experience.17号染色体等臂染色体（i17q）异常与髓系肿瘤患者的临床特征及治疗结果：单中心经验
Leuk Res Rep. 2018 Jun 20;10:55-56. doi: 10.1016/j.lrr.2018.06.002. eCollection 2018.
2
Blast crisis of Ph-positive chronic myeloid leukemia with isochromosome 17q: report of 12 cases and review of the literature.伴有17号染色体长臂等臂染色体的Ph阳性慢性髓性白血病急变期：12例报告并文献复习
Leuk Lymphoma. 2000 Jun;38(1-2):83-90. doi: 10.3109/10428190009060321.
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Myeloid Neoplasms with Isolated Isochromosome 17q: a yet to be Defined Entity.伴有孤立性17号染色体等臂染色体的髓系肿瘤：一个尚未明确的实体。
Mediterr J Hematol Infect Dis. 2017 Nov 1;9(1):e2017066. doi: 10.4084/MJHID.2017.066. eCollection 2017.
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Concomitant isochromosome 17q and mutated in a myelodysplastic syndrome patient with a poor prognosis.一名预后不良的骨髓增生异常综合征患者同时存在17号染色体等臂染色体和突变。
Int J Clin Exp Pathol. 2017 Sep 1;10(9):9786-9792. eCollection 2017.
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Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS.伴有孤立性17号染色体长臂等臂染色体的髓系肿瘤在SETBP1、SRSF2、ASXL1和NRAS中显示出高频突变。
Oncotarget. 2016 Mar 22;7(12):14251-8. doi: 10.18632/oncotarget.7350.
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Cytogenetic evaluation of isochromosome 17q in posterior fossa tumors of children and correlation with clinical outcome in medulloblastoma. Detection of a novel chromosomal abnormality.儿童后颅窝肿瘤中17号染色体长臂等臂染色体的细胞遗传学评估及其与髓母细胞瘤临床结局的相关性。一种新型染色体异常的检测。
Childs Nerv Syst. 2002 Aug;18(8):380-4. doi: 10.1007/s00381-002-0617-9. Epub 2002 Jul 27.
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Case report of isochromosome 17q in acute myeloid leukemia with myelodysplasia-related changes after treatment with a hypomethylating agent.急性髓系白血病伴骨髓增生异常相关改变患者经去甲基化药物治疗后出现17号染色体等臂染色体的病例报告。
Genet Mol Res. 2012 Aug 6;11(3):2045-50. doi: 10.4238/2012.August.6.8.
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Isolated isochromosome 17q: a distinct type of mixed myeloproliferative disorder/myelodysplastic syndrome with an aggressive clinical course.孤立性17号染色体长臂等臂染色体：一种具有侵袭性临床病程的独特类型的混合性骨髓增殖性疾病/骨髓增生异常综合征。
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GCSF gene is expressed but not rearranged in a patient with isochromosome 17q positive acute nonlymphocytic leukemia.
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Isochromosome 17q in childhood acute lymphoblastic leukemia: an adverse cytogenetic feature in association with hyperdiploidy?儿童急性淋巴细胞白血病中的17号染色体等臂染色体：与超二倍体相关的不良细胞遗传学特征？
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本文引用的文献

1
Isochromosome 17q10 associated with basophilia in primary myelofibrosis while with JAK2 inhibitor.
Ann Hematol. 2015 Aug;94(8):1421-2. doi: 10.1007/s00277-015-2380-5. Epub 2015 Apr 22.
2
Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV.诊断时附加细胞遗传学异常对 CML 预后的影响：来自随机 CML 研究 IV 的 1151 例患者的长期观察。
Blood. 2011 Dec 22;118(26):6760-8. doi: 10.1182/blood-2011-08-373902. Epub 2011 Oct 28.
3
Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic/myeloproliferative features, a high risk of leukemic transformation, and wild-type TP53.孤立性 17q 等臂染色体髓系肿瘤是一种临床病理实体，与骨髓增生异常/骨髓增殖性特征、白血病转化风险高和野生型 TP53 相关。
Prognostic significance of isochromosome 17q in hematologic malignancies.
17号染色体等臂染色体在血液系统恶性肿瘤中的预后意义
Oncotarget. 2021 Mar 30;12(7):708-718. doi: 10.18632/oncotarget.27914.
Cancer. 2012 Jun 1;118(11):2879-88. doi: 10.1002/cncr.26537. Epub 2011 Oct 28.
4
Blast crisis of Ph-positive chronic myeloid leukemia with isochromosome 17q: report of 12 cases and review of the literature.伴有17号染色体长臂等臂染色体的Ph阳性慢性髓性白血病急变期：12例报告并文献复习
Leuk Lymphoma. 2000 Jun;38(1-2):83-90. doi: 10.3109/10428190009060321.
5
Isolated isochromosome 17q: a distinct type of mixed myeloproliferative disorder/myelodysplastic syndrome with an aggressive clinical course.孤立性17号染色体长臂等臂染色体：一种具有侵袭性临床病程的独特类型的混合性骨髓增殖性疾病/骨髓增生异常综合征。
Br J Haematol. 1999 Aug;106(2):445-54. doi: 10.1046/j.1365-2141.1999.01537.x.