Raats Daan, Lorent Natalie, Saegeman Veroniek, Vos Robin, van Ingen Jakko, Verleden Geert, Van Raemdonck Dirk, Dupont Lieven
Department of Pneumology, University Hospitals Leuven, Leuven, Belgium.
Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
Transpl Infect Dis. 2019 Apr;21(2):e13046. doi: 10.1111/tid.13046. Epub 2019 Jan 13.
Pulmonary Mycobacterium abscessus infection in cystic fibrosis (CF) patients is difficult to treat and considered a contra-indication for lung transplantation in most centers. We present four CF patients with chronic pulmonary M abscessus infection, in whom lung transplantation was performed. Through intensive treatment before transplantation, we achieved control of the infection in all but one patient. After a mean of 16 months of follow up, 3 patients are doing well, without evidence of local or disseminated recurrence. One patient died early post-transplant due to an unrelated cause. These findings support the possibility of lung transplantation with favorable outcome in CF patients with M abscessus infection.
囊性纤维化（CF）患者的肺部脓肿分枝杆菌感染难以治疗，在大多数中心被视为肺移植的禁忌症。我们报告了4例患有慢性肺部脓肿分枝杆菌感染的CF患者，他们接受了肺移植手术。通过移植前的强化治疗，除1例患者外，我们成功控制了所有患者的感染。平均随访16个月后，3例患者情况良好，无局部或播散性复发迹象。1例患者在移植后早期因无关原因死亡。这些发现支持了患有脓肿分枝杆菌感染的CF患者进行肺移植并取得良好预后的可能性。
