Beckett Robert D, Stump Curtis D, Dyer Megan A
Associate Professor of Pharmacy Practice and Director of the Drug Information Center, College of Pharmacy, Natural & Health Sciences, Manchester University, Fort Wayne, IN,
Doctor of Pharmacy Student, College of Pharmacy, Natural & Health Sciences, Manchester University, Fort Wayne, IN,
J Med Libr Assoc. 2019 Jan;107(1):62-71. doi: 10.5195/jmla.2019.549. Epub 2019 Jan 1.
The research evaluated point-of-care drug interaction resources for scope, completeness, and consistency in drug-ethanol and drug-tobacco content.
In a cross-sectional analysis, 2 independent reviewers extracted data for 108 clinically relevant interactions using 7 drug information resources (Clinical Pharmacology Drug Interaction Report, Facts & Comparisons eAnswers, Lexicomp Interactions, Micromedex Drug Interactions, and ). Scope (presence of an entry), completeness (content describing mechanism, clinical effects, severity, level of certainty, and course of action for each present interaction; up to 1 point per assessed item for a total possible score of 5 points), and consistency (similarity among resources) were evaluated.
Fifty-three drug-ethanol and 55 drug-tobacco interactions were analyzed. Drug-ethanol interaction entries were most commonly present in Lexicomp (84.9%), Clinical Pharmacology (83.0%), and (73.6%), compared to other resources (<0.05). Drug-tobacco interactions were more often covered in Micromedex (56.4%), (56.4%), Drug Interaction Facts (43.6%), and Clinical Pharmacology (41.8%) (<0.001). Overall completeness scores were higher for Lexicomp, Micromedex, and Facts & Comparisons (median 5/5 points, interquartile range [IQR] 5 to 5, <0.001) for drug-ethanol and for Micromedex (median 5/5 points, IQR 5 to 5, <0.05) for drug-tobacco, compared to other resources. and Micromedex were among the highest scoring resources for both drug-ethanol (73.7%, 68.6%) and drug-tobacco (75.0%, 32.3%) consistency.
Scope and completeness were high for drug-ethanol interactions, but low for drug-tobacco interactions. Consistency was highly variable across both interaction types.
本研究评估了即时护理药物相互作用资源在药物 - 乙醇和药物 - 烟草内容方面的范围、完整性和一致性。
在一项横断面分析中，两名独立评审员使用7种药物信息资源（临床药理学药物相互作用报告、Facts & Comparisons电子答案、Lexicomp相互作用、Micromedex药物相互作用等）提取了108种临床相关相互作用的数据。评估了范围（是否有条目）、完整性（描述每种现有相互作用的机制、临床效果、严重程度、确定性水平和行动方案的内容；每个评估项目最高1分，总可能分数为5分）和一致性（资源之间的相似性）。
分析了53种药物 - 乙醇和55种药物 - 烟草相互作用。与其他资源相比（<0.05），药物 - 乙醇相互作用条目最常见于Lexicomp（84.9%）、临床药理学（83.0%）等（73.6%）。药物 - 烟草相互作用在Micromedex（56.4%）、等（56.4%）、药物相互作用事实（43.6%）和临床药理学（41.8%）中报道得更多（<0.001）。与其他资源相比，Lexicomp、Micromedex等和Facts & Comparisons在药物 - 乙醇方面的总体完整性得分较高（中位数5/5分，四分位间距[IQR]5至5，<0.001），Micromedex在药物 - 烟草方面的总体完整性得分较高（中位数5/5分，IQR 5至5，<0.05）。在药物 - 乙醇（73.7%，68.6%）和药物 - 烟草（75.0%，32.3%）一致性方面，等和Micromedex是得分最高的资源之一。
药物 - 乙醇相互作用的范围和完整性较高，但药物 - 烟草相互作用的范围和完整性较低。两种相互作用类型的一致性差异很大。
