Denjean A, Roux C, Herve P, Bonniot J P, Comoy E, Duroux P, Gaultier C
Laboratoire de Physiologie, Hôpital Antoine Béclère, Clamart, France.
Am Rev Respir Dis. 1988 Oct;138(4):789-93. doi: 10.1164/ajrccm/138.4.789.
We studied the effect of mild isocapnic hypoxia (FIO2 = 15.5%) on lung mechanics, heart rate, circulating plasma catecholamines, and bronchial responsiveness to methacholine in ten asthmatic adults. Hypoxia did not alter lung mechanics (i.e., dynamic pulmonary compliance [CLdyn], pulmonary resistance [RL]) nor did it increase plasma catecholamines, but it significantly increased bronchial responsiveness to aerosolized methacholine, as assessed by the fall in forced expiratory volume in one second (FEV1: 1.2 +/- 0.18 versus 0.9 +/- 0.14 L/s, p less than 0.05), the rise in RL (RL: 19.1 +/- 1.4 versus 8.4 +/- 1 cm H2O/L/s, p less than 0.05), and the steeper slope of the dose-response curve to methacholine. We concluded that the hypoxic characteristic of asthmatic attacks may aggravate airflow obstruction.
我们研究了轻度等容性低氧（FIO2 = 15.5%）对10名成年哮喘患者肺力学、心率、循环血浆儿茶酚胺以及支气管对乙酰甲胆碱反应性的影响。低氧并未改变肺力学（即动态肺顺应性[CLdyn]、肺阻力[RL]），也未增加血浆儿茶酚胺，但通过一秒用力呼气量的下降（FEV1：1.2±0.18与0.9±0.14 L/s，p<0.05）、RL的升高（RL：19.1±1.4与8.4±1 cm H2O/L/s，p<0.05）以及对乙酰甲胆碱剂量反应曲线更陡的斜率评估，它显著增加了支气管对雾化乙酰甲胆碱的反应性。我们得出结论，哮喘发作的低氧特征可能会加重气流阻塞。
