一名4个月大男童因产AmpCβ-内酰胺酶且孔蛋白缺失导致对碳青霉烯类耐药的脓毒症。
Sepsis in a 4-Month-Old Boy Due to Carbapenem-Resistant Characterized by AmpC β-Lactamase with Porin Loss.
作者信息
Shimizu Junji, Taga Takashi, Sato Tomomi, Eguchi Yutaka
机构信息
Department of Emergency and Intensive Care Unit, Shiga University of Medical Science, Otsu, Shiga, Japan.
Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan.
出版信息
Int J Appl Basic Med Res. 2018 Oct-Dec;8(4):263-265. doi: 10.4103/ijabmr.IJABMR_383_17.
The incidence of carbapenem-resistant (CRE) infections is increasing, and these infections are associated with both morbidity and mortality. However, little is known about CRE infections in children. This article is a case report describing a 4-month-old boy with Langerhans histiocytosis who developed septic shock due to a CRE infection. The mechanism of carbapenem resistance was identified as AmpC β-lactamase hyperproduction with porin loss. The patient was treated with antibiotics, volume resuscitation, and vasopressors; however, he died of multiorgan failure due to CRE infection. Clinicians should be aware of the prevalence of CRE and the importance of prevention strategies against infection with multidrug-resistant bacteria, even in pediatric populations.
耐碳青霉烯类肠杆菌科细菌（CRE）感染的发生率正在上升，并且这些感染与发病率和死亡率均相关。然而，关于儿童CRE感染的情况却知之甚少。本文是一例病例报告，描述了一名4个月大患朗格汉斯细胞组织细胞增多症的男婴，他因CRE感染而发生感染性休克。碳青霉烯耐药机制被确定为AmpCβ-内酰胺酶过度产生伴孔蛋白缺失。患者接受了抗生素、液体复苏和血管活性药物治疗；然而，他因CRE感染死于多器官功能衰竭。临床医生应意识到CRE的流行情况以及针对多重耐药菌感染的预防策略的重要性，即使在儿科人群中也是如此。
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