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慢性多灶性骨髓炎:类鼻疽的一种罕见表现。

Chronic multifocal osteomyelitis: A rare presentation of melioidosis.

作者信息

Alexander Vijay, Koshy Maria, Shenoy Rachana, Sudarsanam Thambu David

机构信息

Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

出版信息

J Family Med Prim Care. 2018 Sep-Oct;7(5):1133-1135. doi: 10.4103/jfmpc.jfmpc_227_18.

DOI:10.4103/jfmpc.jfmpc_227_18
PMID:30598977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6259495/
Abstract

A 45-year-old gentleman presented with fever, weight loss, and painful swelling of both knees. His history was significant for type 2 diabetes mellitus. Blood cultures grew , and imaging revealed osteomyelitis of bilateral distal femura and proximal tibiae, with no involvement of the joint space. He underwent debridement and was initiated on ceftazidime followed by eradication therapy with trimethoprim-sulfamethoxazole. He recovered well with no further complications. Melioidosis is a rare cause of multifocal osteomyelitis and is a differential to be considered in an appropriate clinicoepidemiological setting.

摘要

一名45岁男性患者出现发热、体重减轻以及双膝疼痛性肿胀。他有2型糖尿病病史。血培养结果呈阳性,影像学检查显示双侧股骨远端和胫骨近端骨髓炎,关节间隙未受累。他接受了清创术,并开始使用头孢他啶治疗,随后用复方新诺明进行根除治疗。他恢复良好,没有出现进一步的并发症。类鼻疽是多灶性骨髓炎的罕见病因,在适当的临床流行病学背景下是需要考虑的鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d08/6259495/ccdafe83fc0c/JFMPC-7-1133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d08/6259495/ccdafe83fc0c/JFMPC-7-1133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d08/6259495/ccdafe83fc0c/JFMPC-7-1133-g001.jpg

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本文引用的文献

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Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis.预测假鼻疽伯克霍尔德菌的全球分布和类鼻疽病负担。
Nat Microbiol. 2016 Jan 11;1:15008. doi: 10.1038/nmicrobiol.2015.8.
2
Multifocal melioidosis with femoral osteomyelitis in a healthy 25-year-old traveller.一名25岁健康旅行者患多灶性类鼻疽伴股骨骨髓炎
BMJ Case Rep. 2016 Jul 18;2016:bcr2016216356. doi: 10.1136/bcr-2016-216356.
3
India is at high risk from surge in cases of melioidosis, warn researchers.研究人员警告称,印度面临类鼻疽病例激增的高风险。
BMJ. 2016 Jan 15;352:i275. doi: 10.1136/bmj.i275.
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Burkholderia Pseudomallei Causing Bone and Joint Infections: A Clinical Update.伯克霍尔德菌假单胞菌引起的骨和关节感染:临床更新。
Infect Dis Ther. 2016 Mar;5(1):17-29. doi: 10.1007/s40121-015-0098-2. Epub 2016 Jan 4.
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Am J Trop Med Hyg. 2013 Mar;88(3):411-413. doi: 10.4269/ajtmh.12-0555.
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N Engl J Med. 2012 Sep 13;367(11):1035-44. doi: 10.1056/NEJMra1204699.
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The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study.类鼻疽病的流行病学和临床谱:来自达尔文前瞻性研究 20 年的 540 例病例。
PLoS Negl Trop Dis. 2010 Nov 30;4(11):e900. doi: 10.1371/journal.pntd.0000900.
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Melioidosis as a cause of multifocal osteomyelitis.类鼻疽作为多灶性骨髓炎的病因。
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