Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China; Child Development and Learning Science, Key Laboratory of Ministry of Education, China.
J Affect Disord. 2019 Mar 1;246:498-505. doi: 10.1016/j.jad.2018.12.066. Epub 2018 Dec 26.
Somatic symptoms are common among patients with major depressive disorder (MDD), and are known to negatively impact the course and severity of the disease. Although previous studies have attempted to explore the neuropathology of MDD, little is known regarding the neural basis of somatic symptoms in MDD.
Resting-state functional magnetic resonance images of 28 MDD patients with somatic symptoms (somatic depression, SD), 30 patients without somatic symptoms (non-somatic depression, NSD) and 30 healthy controls (HC) were obtained. We investigated the neural basis of MDD with somatic symptoms based on the measure of regional homogeneity (ReHo). We also investigated whether the altered regional homogeneity may be correlated to any clinical features of depression. These comparison were also carried out in female and male subjects respectively.
The SD exhibited higher ReHo in the bilateral parahippocampus and left lingual gyrus than HC, as well as lower ReHo in the right frontal gyrus. Relative to NSD, the SD exhibited lower ReHo in the right middle frontal gyrus and left precentral gyrus. Furthermore, in the SD, ReHo in the left precentral gyrus was positively correlated with cognitive factor scores of the HAMD-17. In female subjects, SD exhibited increased ReHo in the right STG and decreased ReHo in the right MFG, relative to women of the NSD group.
Our preliminary findings indicated that abnormal ReHo in the frontal and temporal regions may play an important role in the neural basis of somatic depression.
躯体症状在重度抑郁症（MDD）患者中很常见，并且已知会对疾病的过程和严重程度产生负面影响。尽管先前的研究试图探索 MDD 的神经病理学，但对于 MDD 躯体症状的神经基础知之甚少。
对 28 名有躯体症状的 MDD 患者（躯体性抑郁，SD）、30 名无躯体症状的患者（非躯体性抑郁，NSD）和 30 名健康对照者（HC）进行了静息态功能磁共振成像。我们基于局部一致性（ReHo）来研究具有躯体症状的 MDD 的神经基础。我们还研究了改变的局部一致性是否与抑郁的任何临床特征相关。这些比较也分别在女性和男性受试者中进行。
SD 组双侧海马旁回和左侧舌回的 ReHo 高于 HC 组，右侧额上回的 ReHo 低于 HC 组。与 NSD 相比，SD 组右侧额中回和左侧中央前回的 ReHo 较低。此外，在 SD 中，左侧中央前回的 ReHo 与 HAMD-17 的认知因子评分呈正相关。在女性受试者中，SD 组右侧 STG 的 ReHo 增加，右侧 MFG 的 ReHo 降低，与 NSD 组的女性相比。
我们的初步研究结果表明，额叶和颞叶区域的异常 ReHo 在躯体性抑郁的神经基础中可能起着重要作用。
