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汉族人群 HLA-A*3201 等位基因与奥卡西平诱导的皮肤不良反应的相关性。

Association between HLA-A*3201 allele and oxcarbazepine-induced cutaneous adverse reactions in Eastern Han Chinese population.

机构信息

Department of Neurology & Institute of Neurology, Huai'an Third People's Hospital, Jiangsu Province, China.

Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Seizure. 2019 Feb;65:25-30. doi: 10.1016/j.seizure.2018.12.011. Epub 2018 Dec 18.

DOI:10.1016/j.seizure.2018.12.011
PMID:30599396
Abstract

PURPOSE

To determine genetic associations between oxcarbazepine (OXC)-induced cutaneous adverse drug reactions (cADRs) and human leukocyte antigen (HLA) variants in the Eastern Han Chinese population.

METHODS

A total of 120 patients were enrolled in this study, including 30 subjects with OXC-induced cADRs (case group) and 90 OXC-tolerant patients (control group). High-resolution HLA genotyping was conducted for HLA-A, HLA-B, HLA-C, and HLA-DRB1, and allele frequencies were compared.

RESULTS

No patient carried the HLA-B 1502 allele in the case group, the frequency of HLA-B 1502 allele in the control group was 6.1%. HLA-A3201 allele was detected in 13.3% of 30 patients with OXC-induced cADRs (4/30) and 0% of 90 OXC-tolerant patients (0/90). The difference in HLA-A3201 frequency between the two groups was statistically significant [P = 0.004, odds ratio (OR) = 15.877, 95% confidence interval (CI) = 1.817-138.720].

CONCLUSIONS

Eastern Han Chinese patients with the HLA-A3201 allele may be more susceptible to OXC-induced cADRs, while the HLA-B1502 allele is not correlated with it. The precise association between HLA alleles and OXC-induced cADRs warrants further study.

摘要

目的

在汉族人群中,确定奥卡西平(OXC)诱导的皮肤不良反应(cADR)与人类白细胞抗原(HLA)变体之间的遗传关联。

方法

本研究共纳入 120 例患者,包括 30 例 OXC 诱导的 cADR 患者(病例组)和 90 例 OXC 耐受患者(对照组)。对 HLA-A、HLA-B、HLA-C 和 HLA-DRB1 进行高分辨率 HLA 基因分型,并比较等位基因频率。

结果

病例组中无患者携带 HLA-B1502 等位基因,对照组中 HLA-B1502 等位基因的频率为 6.1%。在 30 例 OXC 诱导的 cADR 患者中(4/30)检测到 HLA-A3201 等位基因,而在 90 例 OXC 耐受患者中(0/90)未检测到。两组 HLA-A3201 频率差异有统计学意义[P=0.004,比值比(OR)=15.877,95%置信区间(CI)=1.817-138.720]。

结论

汉族患者 HLA-A3201 等位基因可能更容易发生 OXC 诱导的 cADR,而 HLA-B1502 等位基因与之无关。HLA 等位基因与 OXC 诱导的 cADR 之间的确切关联需要进一步研究。

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