2009 年至 2017 年期间德国患者中丙戊酸的使用趋势。
Trends in valproate use in patients in Germany between 2009 and 2017.
机构信息
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
Department of Neurology, Vivantes Humboldt-Klinikum, Berlin, Germany.
出版信息
Epilepsy Behav. 2019 Mar;92:26-30. doi: 10.1016/j.yebeh.2018.12.002. Epub 2018 Dec 31.
OBJECTIVE
The goal of this study was to analyze trends in valproate use in patients followed by neurologists and general practitioners in Germany between 2009 and 2017.
METHODS
This study included all patients aged ≥15 years followed in 2009, 2013, and 2017 in neurological (N = 99) and general (N = 499) practices in Germany. Trends in valproate use were estimated based on the mean number of patients per practice who were prescribed valproate and the proportion of physicians prescribing it. Covariables included gender, age, and physician. This cross-sectional study uses descriptive statistics only.
RESULTS
In total, 1,298,446 patients were followed in general and neurological practices in 2009, 1,358,160 in 2013, and 1,413,286 in 2017. The mean number of patients aged 15-45 years per practice with at least one valproate prescription decreased in neurological (men: 11.07 versus 9.92; women: 9.27 versus 5.88) and general practices (men: 0.82 versus 0.75; women: 0.60 versus 0.37) between 2009 and 2017. Moreover, the proportion of neurologists prescribing valproate in women between 15 and 45 years of age decreased over time (94% in 2009 versus 86% in 2017), and there was also a substantial decrease in the share of general practitioners prescribing valproate in men (47% versus 41%) and women between 15 and 45 years of age (37% versus 22%).
CONCLUSION
The proportion of men and women between 15 and 45 years of age receiving valproate decreased in neurological and general practices in Germany between 2009 and 2017.
目的
本研究旨在分析 2009 年至 2017 年间德国神经科医生和全科医生随访的患者中丙戊酸的使用趋势。
方法
本研究纳入了德国所有 2009 年、2013 年和 2017 年在神经科（N=99）和全科（N=499）诊所随访的≥15 岁患者。根据每位医生开出丙戊酸盐的患者人数和开具该药物的医生比例，评估丙戊酸的使用趋势。协变量包括性别、年龄和医生。本横断面研究仅使用描述性统计。
结果
2009 年、2013 年和 2017 年，共有 1298446 名患者在普通和神经科诊所接受随访，1358160 名患者在普通和神经科诊所接受随访，1413286 名患者在普通和神经科诊所接受随访。2009 年至 2017 年，每位 15-45 岁有至少一张丙戊酸盐处方的医生所治疗的患者人数（男性：11.07 例比 9.92 例；女性：9.27 例比 5.88 例）和普通科医生（男性：0.82 例比 0.75 例；女性：0.60 例比 0.37 例）呈下降趋势。此外，随着时间的推移，15-45 岁女性开丙戊酸盐的神经科医生比例下降（2009 年为 94%，2017 年为 86%），同时，15-45 岁男性和女性开丙戊酸盐的全科医生比例也大幅下降（47%比 41%）和（37%比 22%）。
结论
2009 年至 2017 年间，德国神经科和普通科诊所 15-45 岁男性和女性接受丙戊酸治疗的比例下降。
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