a Psychiatry & Clinical Psychobiology , Division of Neuroscience, Scientific Institute Ospedale San Raffaele , Milano , Italy.
b University Vita-Salute San Raffaele , Milano , Italy.
Expert Rev Neurother. 2019 Feb;19(2):159-172. doi: 10.1080/14737175.2019.1562338. Epub 2019 Jan 1.
The fronto-limbic network has been suggested as a key circuitry in the pathophysiology and maintenance of bipolar disorder. In the past decade, a disrupted connectivity within prefrontal-limbic structures was identified as a promising candidate biomarker for the disorder. Areas Covered: In this review, the authors examine current literature in terms of the structural, functional and effective connectivity in bipolar disorder, integrating recent findings of imaging genetics and machine learning. This paper profiles the current knowledge and identifies future perspectives to provide reliable and usable neuroimaging biomarkers for bipolar psychopathology in clinical practice. Expert Opinion: The replication and the translation of acquired knowledge into useful and usable tools represents one of the current greatest challenges in biomarker research applied to psychiatry.
额眶-边缘网络被认为是双相障碍的病理生理学和维持的关键回路。在过去的十年中，人们发现前额-边缘结构内的连接中断是该疾病有前途的候选生物标志物。
在这篇综述中，作者根据双相障碍的结构、功能和有效连接检查了当前的文献，整合了影像学遗传学和机器学习的最新发现。本文概述了当前的知识，并确定了未来的展望，为临床实践中的双相精神病理学提供可靠和可用的神经影像学生物标志物。
复制和将获得的知识转化为有用和可用的工具是精神病学应用中的生物标志物研究的当前最大挑战之一。
