Gandevia S C
Department of Neurology, Prince Henry Hospital, New South Wales, Australia.
Aust Paediatr J. 1988;24 Suppl 1:104-8.
Fatigue is defined as the failure of muscle to produce the initial peak force. This may be due to failure at one or more sites between the motor cortex, the motoneuron and the internal machinery of the muscle fibre. Issues of the topic under consideration include sensation of motor command during fatigue, voluntary activation of motoneuron pools and motor unit behaviour and electromyographic activity during fatigue. At one end of this motor chain there may be failure to generate an adequate descending voluntary drive to the motoneuron pool causing central fatigue and at the other a failure of excitation-contraction coupling. The contractile apparatus within the cell may also be abnormal. Changes in the central motor commands, the discharge of motoneurons and the output of muscle fibres during muscle fatigue are described.
疲劳被定义为肌肉无法产生初始峰值力。这可能是由于运动皮层、运动神经元和肌纤维内部机制之间的一个或多个部位出现故障。所考虑主题的问题包括疲劳期间的运动指令感觉、运动神经元池的自主激活和运动单位行为以及疲劳期间的肌电图活动。在这个运动链的一端，可能无法产生足够的下行自主驱动至运动神经元池，从而导致中枢性疲劳，而在另一端，则可能出现兴奋 - 收缩偶联失败。细胞内的收缩装置也可能异常。本文描述了肌肉疲劳期间中枢运动指令、运动神经元放电和肌纤维输出的变化。
