Singh Amandeep, Mukhtar Hayat Mohammad, Kaur Hardeep, Kaur Lakhvir
Department of Pharmaceutical Sciences, IKG Punjab Technical University, Kapurthala, India.
Department of Pharmacognosy, Khalsa College of Pharmacy, Amritsar, India.
Nat Prod Res. 2020 Sep;34(17):2514-2517. doi: 10.1080/14786419.2018.1540476. Epub 2019 Jan 2.
This study emphasizes on the investigation of antiplasmodial activity of triterpenoids isolated from leaves. An unsaponified fraction of petroleum ether extract of plant leaves was subjected to silica gel column chromatography which led to the isolation of two known triterpenoids; namely ursolic acid and lupeol. These compounds were evaluated for antiplasmodial activity by schizont maturation inhibition assay using 3D7 Plasmodium strains. Both, ursolic acid and lupeol were found to exhibit significant antiplasmodial effect with an IC value of 18 µg/ml and 3.8 µg/ml, respectively. This study further confirms the traditional role of plant in the treatment of malaria which may be attributed to ursolic acid and lupeol.
本研究着重于对从叶片中分离出的三萜类化合物的抗疟活性进行研究。植物叶片石油醚提取物的未皂化部分经过硅胶柱色谱法处理，从而分离出两种已知的三萜类化合物，即熊果酸和羽扇豆醇。使用3D7疟原虫菌株通过裂殖体成熟抑制试验对这些化合物的抗疟活性进行了评估。结果发现，熊果酸和羽扇豆醇均表现出显著的抗疟效果，其半数抑制浓度（IC）值分别为18微克/毫升和3.8微克/毫升。本研究进一步证实了该植物在治疗疟疾方面的传统作用，这可能归因于熊果酸和羽扇豆醇。
