Leach C S, Johnson P C, Krauhs J M, Cintrón N M
Biomedical Laboratories Branch, Johnson Space Center, Houston, Texas 77058.
Aviat Space Environ Med. 1988 Nov;59(11 Pt 1):1034-7.
Cholesterol, triglycerides, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were measured in blood samples from 125 crewmembers on the first 24 space shuttle flights. Samples were obtained before, immediately after, and 3-23 days after spaceflight. On landing day, only HDL-C was significantly changed from its preflight level; it had decreased 12.8%. Later in the postflight period, total cholesterol and LDL-C as well as HDL-C decreased significantly. Possible causes of these decreases in estimated cholesterol content of lipoprotein fractions include increased levels of thyroxine during flight and reduced physical activity. The postflight decrease in HDL-C is not considered to have clinical significance for shuttle astronauts, but lipoproteins and apolipoproteins should be measured in blood drawn during longer missions.
对参与前24次航天飞机飞行任务的125名机组人员的血样进行了胆固醇、甘油三酯、极低密度脂蛋白胆固醇（VLDL-C）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的检测。在航天飞行前、飞行结束后即刻以及飞行后3至23天采集血样。在着陆日，只有HDL-C与飞行前水平相比有显著变化；其降低了12.8%。在飞行后阶段后期，总胆固醇、LDL-C以及HDL-C均显著降低。脂蛋白组分中估计胆固醇含量降低的可能原因包括飞行期间甲状腺素水平升高以及身体活动减少。对于航天飞机宇航员而言，飞行后HDL-C的降低不被认为具有临床意义，但在执行更长任务期间抽取的血液中应检测脂蛋白和载脂蛋白。
