职业性哮喘中的中性粒细胞活化
Neutrophil activation in occupational asthma.
作者信息
Choi Youngwoo, Lee Youngsoo, Park Hae-Sim
机构信息
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
出版信息
Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):81-85. doi: 10.1097/ACI.0000000000000507.
PURPOSE OF REVIEW
The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace.
RECENT FINDINGS
Increased recruitment and infiltration of neutrophils are found in patients with occupational asthma. Activated neutrophils release several mediators including pro-inflammatory cytokines and extracellular traps, leading to stimulation of airway epithelium and other inflammatory cells.
SUMMARY
New insights into neutrophils in the pathogenesis of occupational asthma may provide a novel approach to the individual patient with occupational asthma.
综述目的
本综述旨在强调中性粒细胞在职业性哮喘患者中的作用。本综述有助于更好地理解、准确诊断和妥善管理工作场所引发的哮喘反应。
最新发现
在职业性哮喘患者中发现中性粒细胞的募集和浸润增加。活化的中性粒细胞释放多种介质，包括促炎细胞因子和细胞外陷阱，导致气道上皮和其他炎症细胞受到刺激。
总结
对职业性哮喘发病机制中中性粒细胞的新见解可能为患有职业性哮喘的个体患者提供一种新方法。
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