韩国精神分裂症患者家庭中明尼苏达多相人格调查表（MMPI）人格维度的遗传度和家族性
Heritability and Familiality of MMPI Personality Dimensions in the Korean Families with Schizophrenia.
作者信息
Jeong Hee Jeong, Lee Byung Dae, Park Je Min, Lee Young Min, Moon Eunsoo, Kim Soo Yeon, Lee Kang Yoon, Suh Hwagyu, Chung Young In
机构信息
Department of Psychiatry, Pusan National University Hospital, Busan, Republic of Korea.
Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
出版信息
Psychiatry Investig. 2018 Dec;15(12):1121-1129. doi: 10.30773/pi.2018.10.21.2. Epub 2018 Dec 19.
OBJECTIVE
Categorical syndrome such as schizophrenia could be the complex of many continuous mental structure phenotypes including several personality development/degeneration dimensions. This is the study to search heritability and familiality of MMPI personality dimensions in the Korean schizophrenic LD (Linkage Disequilibrium) families.
METHODS
We have recruited 204 probands (with schizophrenia) with their parents and siblings whenever possible. We have used MMPI questionnaires for measuring personality and symptomatic dimensions. Heritabilities of personality dimensions in total 543 family members were estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). Personality dimensions in total family members were compared with those in 307 healthy unrelated controls for measuring the familialities using ANOVA analysis.
RESULTS
Seven of the 10 MMPI variables were significantly heritable and were included in the subsequent analyses. The three groups (control, unaffected 1st degree relative, case) were found to be significantly different with the expected order of average group scores for all heritable dimensions.
CONCLUSION
Our results show that the aberrations in several personality dimensions could form the complexity of schizophrenic syndrome as a result of genetic-environment coactions or interactions in spite of some limitations (recruited family, phenotyping).
目的
诸如精神分裂症之类的分类综合征可能是许多连续性心理结构表型的复合体，包括若干人格发展/衰退维度。本研究旨在探寻韩国精神分裂症连锁不平衡（LD）家系中明尼苏达多相人格调查表（MMPI）人格维度的遗传度和家族性。
方法
我们尽可能招募了204名先证者（患有精神分裂症）及其父母和兄弟姐妹。我们使用MMPI问卷来测量人格和症状维度。使用序列寡基因连锁分析程序（SOLAR）估计了总共543名家庭成员中人格维度的遗传度。使用方差分析（ANOVA）将所有家庭成员的人格维度与307名健康无血缘关系的对照者的人格维度进行比较，以测量家族性。
结果
10个MMPI变量中的7个具有显著遗传性，并被纳入后续分析。发现三组（对照组、未患病的一级亲属、病例组）在所有可遗传维度上的平均组得分预期顺序上存在显著差异。
结论
我们的结果表明，尽管存在一些局限性（招募的家系、表型分型），但由于基因-环境的共同作用或相互作用，若干人格维度的异常可能构成精神分裂症综合征的复杂性。
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