Furspan P B, Bohr D F
Department of Physiology, University of Michigan, Ann Arbor.
Clin Physiol Biochem. 1988;6(3-4):122-9.
A great deal of evidence has been presented which suggests that a generalized increase in cell membrane permeability to various ions is a fundamental defect associated with hypertension. In addition, some of the evidence is supportive of a central role of this defect in the pathogenesis of hypertension. The source of this defect may lie in the reduced calcium binding capacity of the cell membrane. Because of this reduced capacity the membrane is less stable and is more permeable to various ions.
大量证据表明，细胞膜对各种离子的通透性普遍增加是与高血压相关的一个基本缺陷。此外，一些证据支持这一缺陷在高血压发病机制中起核心作用。这种缺陷的根源可能在于细胞膜钙结合能力的降低。由于这种能力降低，细胞膜稳定性较差，对各种离子的通透性更高。
