Korkmaz Gökten, Özçetin Mustafa, Çağ Yakup, Yükselmiş Ufuk, Öngel Volkan, Işık Olcay
Süleymaniye Maternity and Children Diseases Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Istanbul, Turkey.
Afr Health Sci. 2018 Jun;18(2):378-383. doi: 10.4314/ahs.v18i2.23.
The thyroid gland and hormonal regulation are among the most important systems to be investigated in pre-term infants. This study sought to investigate thyroid hormone levels of healthy and unhealthy pre-term infants.
The prospective study included 53 consecutive premature infants admitted to the neonatal intensive care unit within a duration of one year. Of these preterm babies, 20 were healthy, while 33 had problems such as asphyxia or RDS. Venous blood samples were collected at baseline 0-24 hours, 7 and 14 days and FT3, FT4, and TSH levels were determined. Other data recorded included demographic characteristics of the patients and clinical variables.
The most frequent health problems were RDS (87.9%), sepsis (30.3%), and retinopathy of prematurity (24.2%). The mean TSH levels showed a consistent decline at three consequent measurements in both groups, which were always significantly lower in unhealthy pre-terms. In both groups, TSH levels showed significant decreases on Day 7 and Day 14 compared to the baseline levels (p<005). The levels of FT3 and FT4 consistently showed significant correlations with gestational week and birth weight at each of the three measurements.
Pre-term infants, especially those having problems, have significant hypothyroxinemia that may require thyroid hormone replacement therapy.
甲状腺及激素调节是早产儿最重要的研究系统之一。本研究旨在调查健康和不健康早产儿的甲状腺激素水平。
这项前瞻性研究纳入了一年内连续入住新生儿重症监护病房的53例早产儿。在这些早产儿中，20例健康，33例有窒息或呼吸窘迫综合征等问题。在基线0 - 24小时、7天和14天时采集静脉血样本，测定FT3、FT4和TSH水平。记录的其他数据包括患者的人口统计学特征和临床变量。
最常见的健康问题是呼吸窘迫综合征（87.9%）、败血症（30.3%）和早产儿视网膜病变（24.2%）。两组连续三次测量时，平均TSH水平均呈持续下降，不健康早产儿的TSH水平始终显著更低。两组中，与基线水平相比，TSH水平在第7天和第14天均显著降低（p<0.05）。在三次测量中的每一次，FT3和FT4水平均与孕周和出生体重呈显著相关性。
早产儿，尤其是有问题的早产儿，存在显著的低甲状腺素血症，可能需要甲状腺激素替代治疗。
