Dutta Sourabh, Singh Sarvendra, Bhattacharya Anish, Venkataseshan Sundaram, Kumar Praveen
Departments of Pediatrics and *Nuclear Medicine, PGIMER, Chandigarh, India. Correspondence to: Prof. Sourabh Dutta, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
Indian Pediatr. 2017 Feb 15;54(2):121-124. doi: 10.1007/s13312-017-1013-6.
To compare thyroid hormone levels between septicemic preterm neonates with and without shock.
Preterm septicemic infants with shock constituted Group A (n=36) and those without shock constituted Group B, with groups matched (1:1) for gestation and postnatal age. Those with maternal thyroid disorders, thyrotropic medication and life expectancy <12 hours were excluded. We compared serum tri-iodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) between the groups by univariate and multivariate (adjusting for SNAPPE-II) analysis.
Median (IQR) TSH was significantly lower in Group A [1.39 (0.83,3.48)] vs Group B [5.1 (2.32,7.19)] mmol/dL (P<0.001). Serum T3 and T4 were also lower in Group A (P<0.001). On multivariate analysis, none of these measures were independently associated with septic shock.
Thyroid hormone levels do not independently predict presence of shock among septic preterms.
比较伴有和不伴有休克的败血症早产儿的甲状腺激素水平。
患有休克的早产败血症婴儿组成A组（n = 36），无休克的早产败血症婴儿组成B组，两组在胎龄和出生后年龄方面进行匹配（1:1）。排除患有母亲甲状腺疾病、接受促甲状腺素治疗以及预期寿命<12小时的婴儿。我们通过单因素和多因素（校正SNAPPE-II）分析比较两组之间的血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）和促甲状腺激素（TSH）水平。
A组的TSH中位数（IQR）[1.39（0.83,3.48）]显著低于B组[5.1（2.32,7.19）]mmol/dL（P<0.001）。A组的血清T3和T4也较低（P<0.001）。多因素分析显示，这些指标均与感染性休克无独立相关性。
甲状腺激素水平不能独立预测败血症早产儿休克的存在。
