聚乳酸/聚己内酯薄膜的机械性能和细胞毒性
Mechanical properties and cytotoxicity of PLA/PCL films.
作者信息
Jeong Heeseok, Rho Jeongwon, Shin Ji-Yeon, Lee Deuk Yong, Hwang Taeseon, Kim Kwang J
机构信息
1Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and Technology, Seoul, 01811 Korea.
2Department of Biomedical Engineering, Daelim University, Anyang, 13916 Korea.
出版信息
Biomed Eng Lett. 2018 Apr 4;8(3):267-272. doi: 10.1007/s13534-018-0065-4. eCollection 2018 Aug.
Thermodynamically immiscible poly(lactic acid) (PLA) and poly(-caprolactone) (PCL) were blended and solution-cast by adding the 3% compatibilizer (tributyl citrate, TBC) of the PCL weight. In the PLA/PCL composition range of 99/1-95/5 wt%, mechanical properties of the PLA/PCL films with TBC were always superior to those of the films without TBC. The tensile strength of 42.9 ± 3.5 MPa and the elongation at break of 10.3 ± 2.7% were observed for the 93/7 PLA/PCL films without TBC, indicating that PCL addition is effective for strength and ductility. However, the tensile strength of 54.1 ± 3.4 MPa and the elongation at break of 8.8 ± 1.8% were found for the 95/5 PLA/PCL with TBC, indicating that the effect of co-addition of PCL and TBC on mechanical properties of the films is more pronounced. No cytotoxicity was observed for the PLA/PCL films regardless of TBC addition.
通过添加占聚己内酯（PCL）重量3%的增容剂（柠檬酸三丁酯，TBC），将热力学上不相容的聚乳酸（PLA）和聚己内酯（PCL）进行共混并溶液浇铸。在PLA/PCL重量比为99/1 - 95/5的组成范围内，添加TBC的PLA/PCL薄膜的机械性能始终优于未添加TBC的薄膜。对于未添加TBC的93/7 PLA/PCL薄膜，观察到其拉伸强度为42.9±3.5 MPa，断裂伸长率为10.3±2.7%，这表明添加PCL对强度和延展性有效。然而，对于添加TBC的95/5 PLA/PCL薄膜，其拉伸强度为54.1±3.4 MPa，断裂伸长率为8.8±1.8%，这表明PCL和TBC共同添加对薄膜机械性能的影响更为显著。无论是否添加TBC，PLA/PCL薄膜均未观察到细胞毒性。
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