内皮祖细胞的分类及其在神经系统疾病中的应用 - Suppr | 超能文献

内皮祖细胞的分类及其在神经系统疾病中的应用

Endothelial Progenitor Cells' Classification and Application in Neurological Diseases.

作者信息

Yuan Jing-Jing, Yang Jing, Sun Shi-Lei, Zhang Rui, Xu Yu-Ming

机构信息

1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 1 Jian-she East Road, Zhengzhou, 450000 Henan China.

2Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000 Henan China.

出版信息

Tissue Eng Regen Med. 2017 Apr 3;14(4):327-332. doi: 10.1007/s13770-017-0043-4. eCollection 2017 Aug.

DOI:10.1007/s13770-017-0043-4

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6171603/

Abstract

The therapeutic effects of endothelial progenitor cells (EPCs) on ischemic stroke have been extensively studied in recent years. However, the differences in early EPCs and endothelial outgrowth cells (EOCs) are still unclear. Clarifications of their respective properties and specific functioning characteristics contribute to better applications of EPCs in ischemic diseases. In this review, we discuss cellular origin, isolation, culture, surface markers of early EPCs and EOCs and relevant applications in neurological diseases. We conclude that EOCs possess all characteristics of true endothelial progenitors and have potent advantages in EPC-based therapies for ischemic diseases. A number of preclinical and clinical applications of EPCs in neurological diseases are under study. More studies are needed to determine the specific characteristics of EPCs and the relevant mechanisms of EPCs for neurological diseases.

摘要

近年来，内皮祖细胞（EPCs）对缺血性中风的治疗作用已得到广泛研究。然而，早期EPCs与内皮祖细胞（EOCs）之间的差异仍不明确。明确它们各自的特性和特定功能特征有助于EPCs在缺血性疾病中得到更好的应用。在这篇综述中，我们讨论了早期EPCs和EOCs的细胞起源、分离、培养、表面标志物以及在神经疾病中的相关应用。我们得出结论，EOCs具备真正内皮祖细胞的所有特征，并且在基于EPCs的缺血性疾病治疗中具有显著优势。目前正在研究EPCs在神经疾病中的一些临床前和临床应用。还需要更多研究来确定EPCs的具体特征以及EPCs在神经疾病中的相关机制。