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同日比较 PET/CT 和 PET/MR 在心脏结节病患者中的应用。

Same day comparison of PET/CT and PET/MR in patients with cardiac sarcoidosis.

机构信息

Departments of Medicine, Medical Imaging, and Medical Biophysics, Western University, London, ON, Canada.

MyHealth Centre, 21589 Richmond Street, Arva, ON, N0M 1C0, Canada.

出版信息

J Nucl Cardiol. 2020 Dec;27(6):2118-2129. doi: 10.1007/s12350-018-01578-8. Epub 2019 Jan 2.

DOI:10.1007/s12350-018-01578-8
PMID:30603887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7749056/
Abstract

BACKGROUND

Inflammatory cardiac disorders, in particular, sarcoidosis, play an important role in left ventricular dysfunction, conduction abnormalities, and arrhythmias. In this study, we compared the imaging characteristics and diagnostic information obtained when patients were imaged sequentially with PET/CT and then with hybrid PET/MRI on the same day following a single F-FDG injection.

METHODS

Ten patients with known or suspected sarcoidosis underwent imaging in sequence of (a) Tc-MIBI, (b) F-FDG with PET/CT, and (c) F-FDG with 3T PET/MRI. Images were compared quantitatively by determination of SUV and SUV on a voxel by voxel basis, and qualitatively by two experienced observers.

RESULTS

When both platforms were compared quantitatively, similar data for the evaluation of enhanced F-FDG uptake were obtained. Qualitatively, there were (1) several instances of normal perfusion with delayed enhancement and/or focal F-FDG uptake, (2) comparable enhanced F-FDG uptake on PET/CT vs. PET/MRI, and (3) diversity in disease patterns with delayed enhancement only, increased F-FDG uptake only, or both.

CONCLUSION

In this limited patient study, PET/CT and PET/MR provided similar diagnostic data for F-FDG uptake, and the concurrent acquisition of MR images provided further insight into the disease process.

摘要

背景

炎症性心脏疾病，尤其是结节病，在左心室功能障碍、传导异常和心律失常中起着重要作用。在这项研究中，我们比较了患者在同一天内先后接受 PET/CT 和杂交 PET/MRI 检查时，使用单次 F-FDG 注射后获得的成像特征和诊断信息。

方法

10 名已知或疑似患有结节病的患者依次接受 Tc-MIBI、（b）F-FDG 联合 PET/CT 和（c）F-FDG 联合 3T PET/MRI 成像。通过体素定量测定 SUV 和 SUV，以及两位有经验的观察者进行定性比较，对图像进行定量比较。

结果

当比较两种平台的定量数据时，获得了用于评估增强 F-FDG 摄取的相似数据。定性上，存在以下情况：（1）正常灌注伴延迟增强和/或局灶性 F-FDG 摄取；（2）PET/CT 与 PET/MRI 上的增强 F-FDG 摄取相当；（3）疾病模式多样化，仅表现为延迟增强、仅表现为 F-FDG 摄取增加，或两者兼有。

结论

在这项有限的患者研究中，PET/CT 和 PET/MR 为 F-FDG 摄取提供了相似的诊断数据，而同时采集的磁共振图像为疾病过程提供了进一步的了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/52dd2a0754b4/12350_2018_1578_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/8bf81c717f88/12350_2018_1578_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/b612f5ca8aba/12350_2018_1578_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/ecd73372628f/12350_2018_1578_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/2a37760d043c/12350_2018_1578_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/ed5d0878bed3/12350_2018_1578_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/da0744a9d8fc/12350_2018_1578_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/52dd2a0754b4/12350_2018_1578_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/8bf81c717f88/12350_2018_1578_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/b612f5ca8aba/12350_2018_1578_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/ecd73372628f/12350_2018_1578_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/2a37760d043c/12350_2018_1578_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/ed5d0878bed3/12350_2018_1578_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/da0744a9d8fc/12350_2018_1578_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e731/7749056/52dd2a0754b4/12350_2018_1578_Fig7_HTML.jpg

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