State Key Laboratory of Biochemical Engineering, Institute of Process Engineering , Chinese Academy of Sciences , Beijing 100190 , China.
ACS Appl Mater Interfaces. 2019 Jan 30;11(4):4408-4415. doi: 10.1021/acsami.8b20089. Epub 2019 Jan 15.
Microgel loading with inorganic nanoparticle (NP) composites attracts interest for various biomedical applications. However, the encapsulation of NPs into microgels usually is a diffusion process driven by osmotic pressure, which depends highly on the concentration of NPs and causes low loading efficiency. In this work, we demonstrate preparation of microgels with ultrahigh content of various nano-objects (up to 92%, wt %) by a gelatin "casting" strategy using porous CaCO particles as templates. This approach could encapsulate various NPs with different charged, hydrophilic, and hydrophobic surfaces, shape, and size within microgels, without causing aggregation or change of physicochemical properties of NPs. The hybrid microgels coupled with properties of both inorganic NPs and hydrogels can be taken as an effective photothermal therapy system with great stability, reusability, and degradability and show high effective photothermal activity which is highly related to the content of NPs within microgels. The strategy of fabrication of microgels with nanocomposites is certified to be simple, facile, and low cost, which has potential applications in cancer therapy, drug delivery, catalysis, detecting system, and sewage treatment.
将无机纳米粒子（NP）复合材料负载到微凝胶中引起了人们对各种生物医学应用的兴趣。然而，NP 通常通过渗透压驱动的扩散过程被封装到微凝胶中，这高度依赖于 NP 的浓度，导致负载效率低。在这项工作中，我们展示了使用多孔 CaCO3 颗粒作为模板，通过明胶“铸造”策略制备具有超高含量各种纳米物体（高达 92%，wt%）的微凝胶的方法。这种方法可以将具有不同带电、亲水和疏水表面、形状和尺寸的各种 NPs 封装在微凝胶内，而不会引起 NPs 的聚集或物理化学性质的变化。与无机 NPs 和水凝胶的性质相结合的混合微凝胶可以作为一种具有高稳定性、可重复使用性和可降解性的有效光热治疗系统，其光热活性非常高，这与微凝胶内 NPs 的含量密切相关。纳米复合材料微凝胶的制备策略被证明简单、简便且成本低，在癌症治疗、药物输送、催化、检测系统和污水处理等方面具有潜在的应用。
