Department of Civil and Environmental Engineering, University of Alberta, 7-203 Donadeo Innovation Centre for Engineering, 9211 - 116 Street, Edmonton, Alberta, T6G 1H9, Canada.
Department of Mechanical Engineering, Khalifa University, Abu Dhabi, UAE.
J Orthop Res. 2019 Mar;37(3):655-664. doi: 10.1002/jor.24213. Epub 2019 Feb 12.
In dysplastic infant hips undergoing abduction harness treatment, cartilage contact pressure is believed to have a role in therapeutic cartilage remodeling and also in the complication of femoral head avascular necrosis. To improve our understanding of the role of contact pressure in the remodeling and the complication, we modeled cartilage contact pressure in cartilaginous infant hips undergoing Pavlik harness treatment. In subject-specific finite element modeling, we simulated contact pressure of normal and dysplastic hips in Pavlik harness at 90° flexion and gravity-induced abduction angles of 40°, 60° and 80°. We demonstrated that morphologies of acetabulum and femoral head both affected contact pressure distributions. The simulations showed that in Pavlik harness, contact pressure was mainly distributed along anterior and posterior acetabulum, leaving the acetabular roof only lightly loaded (normal hip) or unloaded (dysplastic hip). From a mechanobiological perspective, these conditions may contribute to therapeutic remodeling of the joint in Pavlik harness. Furthermore, contact pressure increased with the angle of abduction, until at the extreme abduction angle (80°), the lateral femoral head also contacted the posterior acetabular edge. Contact pressure in this area could contribute to femoral head avascular necrosis by reducing flow in femoral head blood vessels. The contact pressure we simulated can plausibly account for both the therapeutic effects and main adverse effect of abduction harness treatment for developmental dysplasia of the hip. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
在患有发育性髋关节发育不良的婴儿接受髋关节外展吊带治疗的过程中,人们认为软骨接触压力在治疗性软骨重塑中起作用,也与股骨头缺血性坏死的并发症有关。为了更好地了解接触压力在重塑和并发症中的作用,我们对接受帕夫利克吊带治疗的发育性髋关节发育不良婴儿的软骨接触压力进行了建模。在基于个体的有限元模型中,我们模拟了帕夫利克吊带在 90°屈曲和重力引起的 40°、60°和 80°外展角度下正常和发育不良髋关节的软骨接触压力。我们证明了髋臼和股骨头的形态都影响接触压力分布。模拟结果表明,在帕夫利克吊带中,接触压力主要分布在前部和后部髋臼,仅使髋臼顶承受轻微的负荷(正常髋关节)或无负荷(发育不良髋关节)。从机械生物学的角度来看,这些条件可能有助于帕夫利克吊带中关节的治疗性重塑。此外,接触压力随外展角度的增加而增加,直到在极端外展角度(80°),股骨头的外侧也与髋臼后缘接触。该区域的接触压力可能会通过减少股骨头血管中的血流而导致股骨头缺血性坏死。我们模拟的接触压力可以合理地解释髋关节外展吊带治疗发育性髋关节发育不良的治疗效果和主要不良反应。©2019 矫形研究协会。由 Wiley Periodicals, Inc. 出版。J Orthop Res.