Sadeghian S Mahsa, Arthurs Owen J, Li Xinshan, Lewis Cara L, Shefelbine Sandra J
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Department of Radiology, Great Ormond Street Hospital, London, UK.
HSS J. 2023 Nov;19(4):418-427. doi: 10.1177/15563316231193426. Epub 2023 Sep 13.
Abnormal prenatal hip joint loading can lead to compromised hip joint function. Early intervention is crucial for favorable outcomes.
This study investigates the impact of treatment timing (initiation and duration) on cartilage growth and ossification in the proximal femur of infants with developmental dysplasia of the hip, a condition affecting newborns.
We used a mechanobiological model to simulate proximal femur growth during treatment durations of 3 months, 6 months, and a late-start treatment.
The findings indicate that the timing of treatment initiation is crucial, while a longer treatment duration does not contribute to improved morphological development of the hip joint.
Mechanobiological models of growth can be used to develop treatments and therapies that correct loading conditions. Growing bone is particularly sensitive to loading conditions, and altered loading during growth can affect bone shape and functionality.
产前髋关节负荷异常可导致髋关节功能受损。早期干预对于取得良好预后至关重要。
本研究调查治疗时机（开始时间和持续时间）对患有发育性髋关节发育不良的婴儿股骨近端软骨生长和骨化的影响，该病症影响新生儿。
我们使用一个力学生物学模型来模拟治疗持续时间为3个月、6个月以及延迟开始治疗时的股骨近端生长情况。
研究结果表明治疗开始的时机至关重要，而较长的治疗持续时间对髋关节形态发育的改善并无帮助。
生长的力学生物学模型可用于开发纠正负荷状况的治疗方法。正在生长的骨骼对负荷状况特别敏感，生长过程中负荷改变会影响骨骼形状和功能。
