Kamei Tomoyo, Kimura Yuta, Koyanagi Jyunichi, Matsumoto Kaori, Hasegawa Tetsuya, Akimoto Masayuki, Takahashi Tamiko
Faculty of Pharmaceutical Sciences, Josai International University.
Chem Pharm Bull (Tokyo). 2019;67(1):75-78. doi: 10.1248/cpb.c18-00694.
The absolute configuration of (+)-4-(6-methoxy-2-naphthyl)butan-2-ol ((+)-MNBO), a nabumetone metabolite, was determined using 1-fluoroindan-1-carboxylic acid (FICA). Both enantiomers of the FICA methyl esters were derivatized to diastereomeric esters of (+)-MNBO by an ester exchange reaction. The results of H- and F-NMR spectroscopy of the diastereomeric FICA esters of (+)-MNBO confirmed the absolute configuration of (+)-MNBO was (S).
萘丁美酮代谢物（+）-4-（6-甲氧基-2-萘基）丁-2-醇（（+）-MNBO）的绝对构型通过1-氟茚-1-羧酸（FICA）确定。FICA甲酯的两种对映体通过酯交换反应衍生化为（+）-MNBO的非对映体酯。（+）-MNBO的非对映体FICA酯的氢谱和氟谱结果证实（+）-MNBO的绝对构型为（S）型。
