基于氨基茚满醇的手性衍生化试剂用于测定羧酸的绝对构型。

Aminoindanol-based chiral derivatizing agents for the determination of the absolute configuration of carboxylic acids.

机构信息

Department of Chemistry and Research Institute for Natural Sciences, Korea University, Seoul 136-701, Republic of Korea.

出版信息

Org Biomol Chem. 2012 Oct 28;10(40):8051-4. doi: 10.1039/c2ob26168e.

DOI:10.1039/c2ob26168e

PMID:22955968

Abstract

New chiral derivatizing agents have been prepared through a simple, short-step synthesis. The absolute configuration of α-chiral carboxylic acids can be assigned on the basis of the NMR chemical shift difference between diastereomeric esters. Because of the modular structures of the agents, the anisotropic effect could be easily manipulated to afford large chemical shift differences even in polar solvents.

摘要

新的手性衍生试剂已经通过简单的短步骤合成制备得到。基于非对映酯之间的 NMR 化学位移差，可以确定α-手性羧酸的绝对构型。由于试剂具有模块化结构，各向异性效应很容易被操纵，即使在极性溶剂中也能产生较大的化学位移差。