Bartlett Samuel L, Keiter Kimberly M, Zavesky Blane P, Johnson Jeffrey S
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
Synthesis (Stuttg). 2019 Jan;51(1):203-212. doi: 10.1055/s-0037-1610391. Epub 2018 Dec 6.
A sequential benzoylation and multihetero-Cope rearrangement of α-keto ester derived nitrones has been developed. The reaction furnishes a diverse array of complex α-imino ester derivatives. The products can be transformed into amino alcohols via LiAlH reduction.
已开发出一种α-酮酯衍生硝酮的顺序苯甲酰化和多杂环-Cope重排反应。该反应可提供多种复杂的α-亚氨基酯衍生物。通过LiAlH还原,产物可转化为氨基醇。