酮肟由酮和羟胺形成的简单反应条件。
Simple reaction conditions for the formation of ketonitrones from ketones and hydroxylamines.
机构信息
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada, K1N 6N5.
出版信息
J Org Chem. 2009 Nov 6;74(21):8381-3. doi: 10.1021/jo901653d.
PMID:19791735
Abstract
The condensation of ketones and hydroxylamines to form ketonitrones was reinvestigated by using thermal conditions previously found to minimize hydroxylamine decomposition (t-BuOH, 110 degrees C). This simple approach allows the formation of exocyclic, acyclic, and alpha,beta-unsaturated ketonitrones with benzylic, linear, and branched nitrogen substituents in modest to excellent isolated yields.
摘要
酮和羟胺缩合形成亚硝酮的反应条件，曾使用过之前发现的能将羟胺分解减到最小的热条件（叔丁醇，110 摄氏度）来重新研究。这种简单的方法可以使具有苄基、线性和支链氮取代基的中环、无环和α，β-不饱和亚硝酮以中等至优异的分离产率形成。
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