早发性和晚发性败血症的管理：80 家德国 NICU 调查结果。
Management of early- and late-onset sepsis: results from a survey in 80 German NICUs.
机构信息
General Pediatrics and Neonatology, Children's Hospital Medical Center, University Hospital of Saarland, Homburg, Germany.
Department of Pediatrics, Children's Hospital, University of Luebeck, Lübeck, Germany.
出版信息
Infection. 2019 Aug;47(4):557-564. doi: 10.1007/s15010-018-1263-9. Epub 2019 Jan 3.
PURPOSE
The management of early- (EOS) and late-onset sepsis (LOS) and neonatal intensive care units (NICUs) has not been extensively evaluated.
METHODS
231 highly specialized level 1 and level 2 NICUs in Germany were asked to participate in an internet-based survey.
RESULTS
The final analysis of anonymized datasets from 80 NICUs (response rate 34.6 %) compared university hospitals and regional neonatal referral centers. The survey describes potential areas of improvement concerning empirical treatment of infants with LOS with vancomycin and 3rd generation cephalosporins, minimal volume of blood sampling for aerobic culture, consideration of lumbar tap in any child with blood culture positive LOS and drug monitoring details for gentamicin and vancomycin.
CONCLUSION
In summary, this survey reveals a significant gap between recent national German guidelines and daily practices in German NICUs.
目的
尚未对早期发病（EOS）和晚期发病（LOS）败血症以及新生儿重症监护病房（NICU）的管理进行广泛评估。
方法
德国 231 家高度专业化的 1 级和 2 级 NICU 被要求参与一项基于互联网的调查。
结果
对来自 80 家 NICU 的匿名数据集的最终分析（响应率为 34.6%）比较了大学医院和区域新生儿转诊中心。该调查描述了在 LOS 患儿使用万古霉素和第三代头孢菌素进行经验性治疗、需氧培养采血最小量、对血培养阳性 LOS 的任何患儿行腰椎穿刺和监测庆大霉素和万古霉素的药物细节方面有改进潜力的领域。
结论
总之，该调查揭示了德国 NICU 最近的国家德国指南与日常实践之间存在显著差距。
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