Pokusa M, Kráľová Trančíková A
Biomedical center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
Physiol Res. 2018 Dec 31;67(Suppl 4):S673-S683. doi: 10.33549/physiolres.934054.
Parkinson's disease (PD) is currently the second most common neurodegenerative disorder in the world. Major features of cell pathology of the disease include the presence of cytoplasmic inclusions called Lewy bodies, which are composed of aggregated proteins. The presence of Lewy's body is associated with more advanced stages of the disease when considering irreversible changes. Precise identification of the disease stage at a cellular level presents the critical tool in developing early diagnostics and/or prevention of PD. The aim of our work is to introduce sensitive microscopic analysis in living cells, focused on initial intracellular changes and thus capable to detect earlier stages of the disease.
帕金森病（PD）是目前世界上第二常见的神经退行性疾病。该疾病细胞病理学的主要特征包括存在称为路易小体的细胞质内含物，其由聚集的蛋白质组成。考虑到不可逆变化时，路易小体的存在与疾病的更晚期阶段相关。在细胞水平上精确识别疾病阶段是开发帕金森病早期诊断和/或预防方法的关键工具。我们工作的目的是引入对活细胞的灵敏显微镜分析，重点关注细胞内的初始变化，从而能够检测该疾病的早期阶段。
