加强证据基础：通过制定 CDC 的儿科轻度创伤性脑损伤指南确定的未来研究建议。
Strengthening the Evidence Base: Recommendations for Future Research Identified Through the Development of CDC's Pediatric Mild TBI Guideline.
机构信息
Kennedy Krieger Institute, and Johns Hopkins University School of Medicine, Baltimore, Maryland (Dr Suskauer); University of Calgary, Alberta, Canada (Dr Yeates); Centers for Disease Control and Prevention, Atlanta, Georgia (Ms Sarmiento and Drs Breiding and Haarbauer-Krupa); Cleveland Clinic, Ohio (Dr Benzel); Goodman Campbell Brain & Spine, Indianapolis, Indiana (Dr Turner); Emory University School of Medicine, Atlanta, Georgia (Dr Weissman); and Stanford University School of Medicine, California (Dr Lumba-Brown). Dr Broomand is retired.
出版信息
J Head Trauma Rehabil. 2019 Jul/Aug;34(4):215-223. doi: 10.1097/HTR.0000000000000455.
OBJECTIVE
The recently published Centers for Disease Control and Prevention evidence-based guideline on pediatric mild traumatic brain injury (mTBI) was developed following an extensive review of the scientific literature. Through this review, experts identified limitations in existing pediatric mTBI research related to study setting and generalizability, mechanism of injury and age of cohorts studied, choice of control groups, confounding, measurement issues, reporting of results, and specific study design considerations. This report summarizes those limitations and provides a framework for optimizing the future quality of research conduct and reporting.
RESULTS
Specific recommendations are provided related to diagnostic accuracy, population screening, prognostic accuracy, and therapeutic interventions.
CONCLUSION
Incorporation of the recommended approaches will increase the yield of eligible research for inclusion in future systematic reviews and guidelines for pediatric mTBI.
目的
最近发布的疾病控制与预防中心（CDC）关于儿童轻度创伤性脑损伤（mTBI）的循证指南是在对科学文献进行广泛审查后制定的。通过这次审查，专家们发现了现有儿童 mTBI 研究在研究环境和普遍性、损伤机制和研究队列的年龄、对照组的选择、混杂因素、测量问题、结果报告以及具体研究设计考虑等方面的局限性。本报告总结了这些局限性，并为优化未来的研究质量和报告提供了框架。
结果
提供了与诊断准确性、人群筛查、预后准确性和治疗干预相关的具体建议。
结论
纳入这些推荐方法将增加未来儿童 mTBI 系统评价和指南中符合条件的研究的数量。
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