Yanagihara Katsunori
Rinsho Byori. 2016 Aug;64(8):942-953.
Inappropriate antimicrobial therapy is associated with a worsening prognosis, and the increasing prevalence of multidrug-resistance organisms has led to significant threats to clinical practice. Bacterial identification and antimicrobial susceptibility testing (AST) are crucial tools for the treatment of bacterial infections. However, information regarding bacterial identification or AST is generally unavailable for clinical decisions regarding treatment for at least two days. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and genetic diagnosis are expected to be newer rapid diagnostic tests for infectious diseases, which contribute to the decision regarding appropriate antimicrobial agents. [Review].
不恰当的抗菌治疗与预后恶化相关，多重耐药菌的日益流行对临床实践构成了重大威胁。细菌鉴定和抗菌药物敏感性测试（AST）是治疗细菌感染的关键工具。然而，关于细菌鉴定或AST的信息通常至少需要两天时间才能用于临床治疗决策。基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）和基因诊断有望成为传染病更新的快速诊断测试，有助于做出关于合适抗菌药物的决策。[综述]
