National Research Council (CNR) , Institute of Applied Sciences & Intelligent Systems (ISASI) 'E. Caianiello' , Via Campi Flegrei 34 , 80078 Pozzuoli ( NA ), Italy.
IRCCS Centro Neurolesi "Bonino-Pulejo" , Contrada Casazza SS113 , 98124 Messina , Italy.
ACS Appl Mater Interfaces. 2019 Jan 23;11(3):3382-3387. doi: 10.1021/acsami.8b12513. Epub 2019 Jan 10.
The numerous advantages of micro- and nanostructures produced by electrospinning (ES) have stimulated enormous interest in this technology with potential application in several fields. However, ES still has some limitations in controlling the geometrical arrangement of the fiber mats so that expensive and time-consuming technologies are usually employed for producing ordered geometries. Here we present a technique that we call "bipolar pyroelectrospinning" (b-PES) for generating ordered arrays of fiber mats in a direct manner by using the bipolar pyroelectric field produced by a periodically poled lithium niobate crystal (PPLN). The b-PES is free from expensive electrodes, nozzles, and masks because it makes use simply of the structured pyroelectric field produced by the PPLN crystal used as collector. The results show clearly the reliability of the technique in producing a wide variety of arrayed fiber mats that could find application in bioengineering or many other fields. Preliminary results of live cells patterning under controlled geometrical constraints is also reported and discussed in order to show potential exploitation as a scaffold in tissue engineering.
静电纺丝（ES）产生的微纳结构具有众多优点，这激发了人们对这项技术的极大兴趣，该技术具有在多个领域应用的潜力。然而，ES 在控制纤维垫的几何排列方面仍存在一些限制，因此通常采用昂贵且耗时的技术来生产有序的结构。在这里，我们提出了一种称为“双极热释电纺丝”（b-PES）的技术，通过使用周期性极化铌酸锂晶体（PPLN）产生的双极热释电场，以直接的方式生成有序的纤维垫阵列。b-PES 无需昂贵的电极、喷嘴和掩模，因为它仅利用用作收集器的 PPLN 晶体产生的结构化热释电场。结果清楚地表明，该技术在生产各种阵列纤维垫方面具有可靠性，这些纤维垫可在生物工程或许多其他领域得到应用。为了展示其在组织工程中作为支架的潜在应用，还报告并讨论了在受控几何约束下对活细胞进行图案化的初步结果。
